Optical control of purinergic signaling

Autor(es)

Wang, Tao ^{[1, 2]} ; Ulrich, Henning ^{[3, 1]} ; Semyanov, Alexey ^{[4, 5]} ; Illes, Peter ^{[1, 6]} ; Tang, Yong ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Chengdu Univ Tradit Chinese Med, Int Collaborat Ctr Big Sci Plan Purinerg Signalli, Chengdu - Peoples R China

^[2] Acupuncture & Chronobiol Key Lab Sichuan Prov, Chengdu - Peoples R China

^[3] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil

^[4] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow - Russia

^[5] Sechenov First Moscow State Med Univ, Moscow - Russia

^[6] Univ Leipzig, Rudolf Boehm Inst Pharmacol & Toxicol, Leipzig - Germany

• Tipo de documento: Artigo de Revisão
• Fonte: PURINERGIC SIGNALLING; v. 17, n. 3, p. 385-392, SEP 2021.
• Citações Web of Science: 0

Resumo

Purinergic signaling plays a pivotal role in physiological processes and pathological conditions. Over the past decades, conventional pharmacological, biochemical, and molecular biology techniques have been utilized to investigate purinergic signaling cascades. However, none of them is capable of spatially and temporally manipulating purinergic signaling cascades. Currently, optical approaches, including optopharmacology and optogenetic, enable controlling purinergic signaling with low invasiveness and high spatiotemporal precision. In this mini-review, we discuss optical approaches for controlling purinergic signaling and their applications in basic and translational science. (AU)

• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático