Inflammation: improving understanding to prevent or ameliorate kidney diseases

Autor(es)

Sheila Marques Fernandes ^[1] ; Mirian Watanabe ; Maria de Fátima Fernandes Vattimo ^[3]

Afiliação do(s) autor(es)

^[1] University of São Paulo. School of Nursing. Animal Model Experimental Laboratory - Brasil

^[3] University of São Paulo. School of Nursing. Animal Model Experimental Laboratory - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 27, 2021-10-18.

Resumo

Abstract Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation may evolve to tissue damage, leading to chronic inflammatory diseases. Inflammation can be considered the major factor involved in the pathological progression of acute and chronic kidney diseases. Functional characteristics of this organ increase its vulnerability to developing various forms of injuries, including acute kidney injury (AKI) and chronic kidney disease (CKD). In view of translational research, several discoveries should be considered regarding the pathogenesis of the inflammatory process, which results in the validation of biomarkers for early detection of kidney diseases. Biomarkers enable the identification of proinflammatory mediators in kidney affections, based on laboratory research applied to clinical practice. Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18. (AU)

• Processo FAPESP: 19/18738-2 - Intervenções não farmacológicas no contexto de doenças crônicas não transmissíveis: o impacto do exercício físico moderado no Diabetes Mellitus e na Doença Renal Crônica
• Beneficiário: Maria de Fatima Fernandes Vattimo
• Modalidade de apoio: Auxílio à Pesquisa - Regular