Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inflammation: improving understanding to prevent or ameliorate kidney diseases

Full text
Author(s):
Sheila Marques Fernandes [1] ; Mirian Watanabe ; Maria de Fátima Fernandes Vattimo [3]
Total Authors: 3
Affiliation:
[1] University of São Paulo. School of Nursing. Animal Model Experimental Laboratory - Brasil
[3] University of São Paulo. School of Nursing. Animal Model Experimental Laboratory - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 27, 2021-10-18.
Abstract

Abstract Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation may evolve to tissue damage, leading to chronic inflammatory diseases. Inflammation can be considered the major factor involved in the pathological progression of acute and chronic kidney diseases. Functional characteristics of this organ increase its vulnerability to developing various forms of injuries, including acute kidney injury (AKI) and chronic kidney disease (CKD). In view of translational research, several discoveries should be considered regarding the pathogenesis of the inflammatory process, which results in the validation of biomarkers for early detection of kidney diseases. Biomarkers enable the identification of proinflammatory mediators in kidney affections, based on laboratory research applied to clinical practice. Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18. (AU)

FAPESP's process: 19/18738-2 - Non pharmacological interventions on noncommunicable diseases: the impact of moderate physical activity on Diabetes Mellitus and on Chronic Kidney Disease
Grantee:Maria de Fatima Fernandes Vattimo
Support Opportunities: Regular Research Grants