Synthetic Routes Towards the Synthesis of Geminal alpha-Difunctionalized Ketones

Autor(es)

Day, David P. ^[1] ; Vargas, Jorge A. M. ^{[1, 2]} ; Burtoloso, Antonio C. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Santiago de Cali, Fac Ciencias Basicas, Calle 5 62-00 Campus Pampalinda, Santiago De Cali - Colombia

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL RECORD; v. 21, n. 10, SI, p. 2837-2854, OCT 2021.
• Citações Web of Science: 1

Resumo

The importance of gem-difunctionalized ketones is represented by their broad applications across chemical boundaries over recent years. The interesting reactivities that this class of compounds possess have made them ideal building blocks to access high-value organic molecules. Furthermore, the gem-difunctionalized ketone moiety has featured in numerous bioactive molecules. For these reasons, a plethora of routes to access such significant molecules have been developed by research groups worldwide - this account looks at delineating the synthesis of gem-difunctionalized ketones from carbonyl substrates, diazo compounds, sulfur ylides and alkynyl reactants. (AU)

• Processo FAPESP: 20/07147-0 - Alfa-heterofuncionalização enantioseletiva de compostos carbonílicos empregando ilídeos sulfoxônios
• Beneficiário: Antonio Carlos Bender Burtoloso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/05002-8 - Investigando Transformações Enantiosseletivas de Diazocetonas e Ilídeos Sulfoxônios.
• Beneficiário: David Philip Day
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado