Synthetic Routes Towards the Synthesis of Geminal alpha-Difunctionalized Ketones

Author(s)

Day, David P. ^[1] ; Vargas, Jorge A. M. ^{[1, 2]} ; Burtoloso, Antonio C. B. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Santiago de Cali, Fac Ciencias Basicas, Calle 5 62-00 Campus Pampalinda, Santiago De Cali - Colombia

• Document type: Journal article
• Source: CHEMICAL RECORD; v. 21, n. 10, SI, p. 2837-2854, OCT 2021.
• Web of Science Citations: 1

Abstract

The importance of gem-difunctionalized ketones is represented by their broad applications across chemical boundaries over recent years. The interesting reactivities that this class of compounds possess have made them ideal building blocks to access high-value organic molecules. Furthermore, the gem-difunctionalized ketone moiety has featured in numerous bioactive molecules. For these reasons, a plethora of routes to access such significant molecules have been developed by research groups worldwide - this account looks at delineating the synthesis of gem-difunctionalized ketones from carbonyl substrates, diazo compounds, sulfur ylides and alkynyl reactants. (AU)

• FAPESP's process: 20/07147-0 - Enantioselective alpha-heterofunctionalization of carbonyl compounds using sulfoxonium ylides
• Grantee: Antonio Carlos Bender Burtoloso
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/05002-8 - Exploration of Enantioselective Transformations of Diazoketones and Sulfoxonium Ylides
• Grantee: David Philip Day
• Support Opportunities: Scholarships in Brazil - Post-Doctoral