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Development of a new methodologies for synthesis of bicyclic aromatic ketones and naphthols employing diazoketones and Beta-keto sulfoxonium ylides

Grant number: 18/03667-0
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2018
Effective date (End): August 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Antonio Carlos Bender Burtoloso
Grantee:Evandro de Azevedo Rocha
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil


The Friedel-Crafts acylation reaction is one of the most important methods for the formation of aromatic ketones. There are several methodologies already described in the literature to obtain this class of compounds. However, these synthetic routes are very similar to the classical method developed by Friedel and Crafts, which use quite a number of supra-stoichiometric reactive Lewis or Brønsted acids, limiting the use of this methodology in multifunctionalized and / or sensitive substrates. Thus, it is proposed the development of a new methodology for the formation of bicyclic aromatic ketones through a synthetic route with few reactional steps and mild conditions. These compounds can be obtained by photochemical reaction in the presence of diazocarbonyl or sulfur ylides (compounds that act as precursors of ketene intermediates capable of promoting intramolecular cyclization similar to the traditional Friedel-Crafts reaction). (AU)

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