Thia-Michael additions and insertion reactions in a,b-unsaturated sulfur ylides
| Grant number: | 18/17244-3 |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| Effective date (Start): | November 01, 2018 |
| Effective date (End): | October 31, 2019 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Principal Investigator: | Antonio Carlos Bender Burtoloso |
| Grantee: | Tharik Azis Castrequini Dahwache |
| Home Institution: | Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
Abstract This project aims to evaluate methodologies for the synthesis of unsaturated bicyclic lactones through the Corey-Chaykovsky reaction, followed by elimination-epoxide opening. The methodology to be evaluated has already been applied in our laboratory for the synthesis of the unsaturated bicyclic lactone 5,5-dimethyltetrahydroisocromen-3(4H)-one, in 35% yield. The project aims to optimize the reaction conditions and increase the substrate scopes, covering different substituents and sizes of the rings. | |