The project in question refers to the synthesis of type II polyketides employing methodologies developed in the group of Prof. Krische. The research group of Prof. Krische has specialized in C-H functionalization of alcohols and unsaturated systems, mediated by organometallic osmium, ruthenium and iridium, generating coupled products with high complexity. Unlike traditional approaches to polyketides, direct alcohol C-C coupling bypasses use of chiral auxiliaries, premetallated C-nucleophiles, and discrete alcohol-to-aldehyde redox reactions. Alcohol C-C coupling will be employed in the synthesis of polyketide like (+)-lactonamycin and arenimycin. These syntheses symbolize strategies by which numerous bioactive type II polyketides may be prepared.
News published in Agência FAPESP Newsletter about the scholarship: