Short-term effect of ligature-induced periodontitis on cardiovascular variability and inflammatory response in spontaneously hypertensive rats

Autor(es)

Ribeiro, Aline Barbosa ^[1] ; da Silva, Thais Marques ^[1] ; Santos-Junior, Nilton Nascimento ^[1] ; Castania, Jaci Airton ^[1] ; Fazan, Jr., Rubens ^[1] ; Salgado, Helio Cesar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ave Bandeirantes, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC ORAL HEALTH; v. 21, n. 1 OCT 11 2021.
• Citações Web of Science: 0

Resumo

Background We previously reported that periodontal disease (PD) induces high arterial pressure variability (APV) consistent with sympathetic overactivity and elicits myocardial inflammation in Balb/c mice. However, it is unknown whether PD can change APV and heart rate variability (HRV) in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. This study aimed to evaluate the hemodynamic level, HRV, and APV associating with myocardial inflammation and plasma concentrations of oxide nitric (NO) in SHR and WKY rats with PD. Methods Three weeks after bilateral ligation of the first mandibular molar, or Sham operation, the rats received catheters into the femoral artery and had their arterial pressure (AP) recorded the following day. Subsequently, plasma, heart, and jaw were collected. The NO was quantified by the chemiluminescence method in plasma, and the myocardial IL-1 beta concentrations were evaluated by ELISA. In the jaw was evaluated linear alveolar bone loss induced by PD. Results The linear alveolar bone loss in jaws of SHR with PD was higher than in all other groups. AP and heart rate were higher in SHR than in their WKY counterparts. SHR with PD showed lower AP than control SHR. HRV and APV were different between SHR and WKY rats; however, no differences in these parameters were found between the animals with PD and their control counterparts. Plasma NO and myocardial IL-1 beta concentrations were higher in SHR with PD as compared to control WKY. A significant correlation was found between linear alveolar bone loss and plasma NO and myocardial IL-1 beta concentrations. Conclusion Our results demonstrated that short-term PD lowered the AP in SHR, which might be due to the higher levels of plasma NO. Even though PD did not affect either HRV or APV, it did induce myocardial inflammation, which can determine cardiovascular dysfunction in long-term PD. (AU)

• Processo FAPESP: 18/20939-3 - Avanços na regulação cardiocirculatória em condições fisiológica e fisiopatológica.
• Beneficiário: Nilton Nascimento dos Santos Júnior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/10455-9 - Papel da ativação elétrica do nervo carotídeo, em ratos acordados, na atenuação das respostas inflamatórias-local e sistêmica-induzidas pela periodontite
• Beneficiário: Aline Barbosa Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/06043-7 - Modulação autonômica (simpática e parassimpática) das respostas inflamatórias e cardiocirculatórias em situações fisiopatológicas clínicas e experimentais
• Beneficiário: Helio Cesar Salgado
• Modalidade de apoio: Auxílio à Pesquisa - Temático