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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short-term effect of ligature-induced periodontitis on cardiovascular variability and inflammatory response in spontaneously hypertensive rats

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Author(s):
Ribeiro, Aline Barbosa [1] ; da Silva, Thais Marques [1] ; Santos-Junior, Nilton Nascimento [1] ; Castania, Jaci Airton [1] ; Fazan, Jr., Rubens [1] ; Salgado, Helio Cesar [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ave Bandeirantes, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: BMC ORAL HEALTH; v. 21, n. 1 OCT 11 2021.
Web of Science Citations: 0
Abstract

Background We previously reported that periodontal disease (PD) induces high arterial pressure variability (APV) consistent with sympathetic overactivity and elicits myocardial inflammation in Balb/c mice. However, it is unknown whether PD can change APV and heart rate variability (HRV) in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. This study aimed to evaluate the hemodynamic level, HRV, and APV associating with myocardial inflammation and plasma concentrations of oxide nitric (NO) in SHR and WKY rats with PD. Methods Three weeks after bilateral ligation of the first mandibular molar, or Sham operation, the rats received catheters into the femoral artery and had their arterial pressure (AP) recorded the following day. Subsequently, plasma, heart, and jaw were collected. The NO was quantified by the chemiluminescence method in plasma, and the myocardial IL-1 beta concentrations were evaluated by ELISA. In the jaw was evaluated linear alveolar bone loss induced by PD. Results The linear alveolar bone loss in jaws of SHR with PD was higher than in all other groups. AP and heart rate were higher in SHR than in their WKY counterparts. SHR with PD showed lower AP than control SHR. HRV and APV were different between SHR and WKY rats; however, no differences in these parameters were found between the animals with PD and their control counterparts. Plasma NO and myocardial IL-1 beta concentrations were higher in SHR with PD as compared to control WKY. A significant correlation was found between linear alveolar bone loss and plasma NO and myocardial IL-1 beta concentrations. Conclusion Our results demonstrated that short-term PD lowered the AP in SHR, which might be due to the higher levels of plasma NO. Even though PD did not affect either HRV or APV, it did induce myocardial inflammation, which can determine cardiovascular dysfunction in long-term PD. (AU)

FAPESP's process: 18/20939-3 - New insights in Cardiovascular Regulation under Physiological and Pathophysiological Condition.
Grantee:Nilton Nascimento dos Santos Júnior
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/10455-9 - Role of electrical activaton of the carotid sinus nerve, in conscious rats, in the attenuation of local and systemic inflammatory response elicited by periodontitis.
Grantee:Aline Barbosa Ribeiro
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 20/06043-7 - Autonomic (sympathetic and parasympathetic) modulation of cardiovascular and inflammatory responses under physiopathological clinical and experimental conditions
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants