Effect of resveratrol supplementation on biomarkers associated with atherosclerosis in humans

Autor(es)

Santana, Tamires Miranda ^{[1, 2]} ; Ogawa, Lucas Yuiiti ^[2] ; Rogero, Marcelo Macedo ^{[1, 3]} ; Barroso, Lucia Pereira ^[4] ; de Castro, Inar Alves ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo Res Fdn, Food Res Ctr FoRC, CEPID FAPESP, Res Innovat & Disseminat Ctr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, LADAF, Av Lineu Prestes 580, B14, BR-05508900 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Nutr Genom & Inflammat Lab, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Math & Stat, Stat Dept, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE; v. 46, FEB 2022.
• Citações Web of Science: 0

Resumo

Previous studies have suggested the beneficial effects of resveratrol against cardiovascular disease (CVD). However, there are inconsistent results on cardiovascular-related biomarkers mainly because of variable dosage, intervention time and baseline characteristics of the population. Thus, the exact effect of resveratrol remains unclear. We conducted a review to classify the studies that applied resveratrol to supplement humans according to the major biomarkers and identify which protocol characteristics would be associated with each result profile. Randomized clinical trials that assessed resveratrol effect on biomarkers related to atherosclerosis were searched in databases. Biochemical data were collected from 27 studies on the baseline and post-intervention time. We selected 12 biomarkers to compose the matrix, based on their clinical relevance and higher variation level. A total of 32 assays were obtained from these 27 studies. The net change (%) was calculated for each biomarker. Applying multivariate analysis, the assays were grouped into 3 clusters. Studies that composed Cluster II were characterized by a mean dose of 454.14 mg/day for 74.21 days and showed higher reduction of triglyceride concentration and blood pressure, while those composing Cluster III applied doses around 273.75 mg/day for about 175.33 days and showed the highest HDL increase. Thus, interventions with resveratrol could be customized according to the patient condition, in terms of ``dose/time of intervention{''}. This information can be applied to combine resveratrol with drugs to reduce blood pressure or improve lipid profile in further clinical studies. (AU)

• Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
• Beneficiário: Bernadette Dora Gombossy de Melo Franco
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs