Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes

Autor(es)

Torello, Cristiane Okuda ^[1] ; Alvarez, Marisa Claudia ^[1] ; Olalla Saad, Sara T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Hematol & Transfus Med Ctr Hemoctr, BR-13083878 Campinas - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 26, n. 19 OCT 2021.
• Citações Web of Science: 0

Resumo

Flavonoids are ubiquitous groups of polyphenolic compounds present in most natural products and plants. These substances have been shown to have promising chemopreventive and chemotherapeutic properties with multiple target interactions and multiple pathway regulations against various human cancers. Polyphenolic flavonoid compounds can block the initiation or reverse the promotion stage of multistep carcinogenesis. Quercetin is one of the most abundant flavonoids found in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) therapy remains a challenge for hematologists worldwide, and the outcomes for patients with both disorders continue to be poor. This scenario indicates the increasing demand for innovative drugs and rational combinative therapies. Herein, we discuss the multitarget effects of the flavonoid quercetin, a naturally occurring flavonol, on AML and MDS.</p> (AU)

• Processo FAPESP: 17/21801-2 - Preditores de gravidade e novos tratamentos para neoplasias da medula óssea
• Beneficiário: Sara Teresinha Olalla Saad
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/08939-7 - Potencial antioxidante do chá verde na quiescência/mobilização de células hematopoéticas mediadas pelo estresse oxidativo e padronização de modelo experimental de leucemia
• Beneficiário: Cristiane Okuda Torello
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado