Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes

Author(s)

Torello, Cristiane Okuda ^[1] ; Alvarez, Marisa Claudia ^[1] ; Olalla Saad, Sara T. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Hematol & Transfus Med Ctr Hemoctr, BR-13083878 Campinas - Brazil

• Document type: Review article
• Source: Molecules; v. 26, n. 19 OCT 2021.
• Web of Science Citations: 0

Abstract

Flavonoids are ubiquitous groups of polyphenolic compounds present in most natural products and plants. These substances have been shown to have promising chemopreventive and chemotherapeutic properties with multiple target interactions and multiple pathway regulations against various human cancers. Polyphenolic flavonoid compounds can block the initiation or reverse the promotion stage of multistep carcinogenesis. Quercetin is one of the most abundant flavonoids found in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) therapy remains a challenge for hematologists worldwide, and the outcomes for patients with both disorders continue to be poor. This scenario indicates the increasing demand for innovative drugs and rational combinative therapies. Herein, we discuss the multitarget effects of the flavonoid quercetin, a naturally occurring flavonol, on AML and MDS.</p> (AU)

• FAPESP's process: 17/21801-2 - Predictors of severity and new treatments for bone marrow neoplasias
• Grantee: Sara Teresinha Olalla Saad
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/08939-7 - Antioxidant potential of green tea in the quiescence/mobilization of hematopoietic cells mediated by oxidative stress and standardization of an experimental model for leukemia
• Grantee: Cristiane Okuda Torello
• Support Opportunities: Scholarships in Brazil - Post-Doctoral