Green coffee extract attenuates Parkinson's-related behaviors in animal models

Autor(es)

Molska, Graziella R. ^{[1, 2]} ; Paula-Freire, Lyvia Izaura G. ^[1] ; Sakalem, Marna E. ^[1] ; Kohn, Daniele O. ^[1] ; Negri, Giuseppina ^[1] ; Carlini, Elisaldo A. ^[3] ; Mendes, Fulvio R. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, ECB, Rua Botucatu 862, 1 Andar, BR-04023062 Sao Paulo, SP - Brazil

^[2] Univ Toronto, Fac Dent, 124 Edward St, Toronto, ON M5G 1G6 - Canada

^[3] Univ Fed Sao Paulo, Dept Med Prevent, Rua Botucatu 740, 4 Andar, BR-04024002 Sao Paulo, SP - Brazil

^[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Rua Arcturus 03, BR-09606070 Sao Bernardo Do Campo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 93, n. 4 2021.
• Citações Web of Science: 0

Resumo

Epidemiological studies have shown an inverse association between coffee consumption and the development of Parkinson's disease (PD). The effects of the oral treatment with green (non-roasted) coffee extracts (CE, 100 or 400 mg/kg) and caffeine (31.2 mg/kg) were evaluated on catalepsy induced by haloperidol in mice, and unilateral 6-OHDA lesion of medial forebrain bundle (MFB) or striatum in rats. Also, the in vitro antioxidant activity and the monoamine levels in the striatum were investigated. CE presented a mild antioxidant activity in vitro and its administration decreased the catalepsy index. CE at the dose of 400 mg/kg induced ipsilateral rotations 14 days after lesion; however, chronic 30-day CE and caffeine treatments did not interfere with the animals' rotation after apomorphine or methamphetamine challenges in animals with MFB lesion, nor on monoamines levels. Furthermore, CE and caffeine were effective in inhibiting the asymmetry between ipsilateral and contralateral rotations induced by methamphetamine and apomorphine in animals with lesion in the striatum but did not avoid the monoamines depletion. These results indicate that CE components indirectly modulate dopaminergic transmission, suggesting a pro-dopaminergic action of CE, and further investigation must be conducted to elucidate the mechanisms of action and the possible neuroprotective role in PD. (AU)

• Processo FAPESP: 06/58692-1 - Avaliacao farmacologica do extrato de cafe (coffea arabica l.) sobre o sistema dopaminergico e em um modelo animal de parkinson.
• Beneficiário: Graziella Rigueira Molska
• Modalidade de apoio: Bolsas no Brasil - Mestrado