herapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui (Colossoma macropomum) parasitized by acanthocephalan (Neoechinorhynchus buttnerae

Autor(es)

Cordeiro, Rafaelle Pereira ^[1] ; de Campos Braga, Patricia Aparecida ^[1] ; Jonsson, Claudio Martin ^[2] ; Brandao, Franmir Rodrigues ^[3] ; Chagas, Edsandra Campos ^[3] ; Reyes Reyes, Felix Guillermo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Food Sci & Nutr, Sch Food Engn, UNICAMP, Campinas, SP - Brazil

^[2] Embrapa Meio Ambiente, Rodovia Governador Dr Adhemar Pereira de Barros, BR-13918110 Jaguariuna, SP - Brazil

^[3] EMBRAPA Amazonia Ocidental, Manaus, Amazonas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AQUACULTURE RESEARCH; v. 53, n. 4 NOV 2021.
• Citações Web of Science: 0

Resumo

The therapeutic efficacy of different doses of albendazole (ABZ) in the treatment of infection by acanthocephalan (Neoechinorhynchus buttnerae) in tambaqui (Colossoma macropomum) was evaluated. The bioaccumulation of ABZ and its main metabolites in the target tissue (muscle plus skin in natural proportions) was also evaluated. The fish received a daily dose of 10, 20 or 30 mg ABZ kg(-1) bw via medicated feed for 34 days. Incorporation of ABZ in the fish feed was performed by coating with ethyl cellulose (EC) (0.75% w/w). The quantitation of ABZ residues and its metabolites in the target tissue was done using a validated ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analytical method. In relation with the therapeutic efficacy, no statistically difference was found between the treated groups. The total residue (sum of ABZ residues and its metabolites) in the target tissue at steady-state was significantly higher for the high dose. Biomagnification factors in all treatments were of low values, indicating that ABZ and its metabolites do not offer the risk of bioaccumulation in the target tissue. Thus, ABZ dose of 10 mg kg(-1) bw is recommend. However, the effect of feed coating on treatment effectiveness and bioaccumulation of albendazole relative to an uncoated feed, and joint therapeutic studies of ABZ with anthelmintic natural products are recommended to be conducted. (AU)

• Processo FAPESP: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
• Beneficiário: Felix Guillermo Reyes Reyes
• Modalidade de apoio: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE