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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

herapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui (Colossoma macropomum) parasitized by acanthocephalan (Neoechinorhynchus buttnerae

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Author(s):
Cordeiro, Rafaelle Pereira [1] ; de Campos Braga, Patricia Aparecida [1] ; Jonsson, Claudio Martin [2] ; Brandao, Franmir Rodrigues [3] ; Chagas, Edsandra Campos [3] ; Reyes Reyes, Felix Guillermo [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Dept Food Sci & Nutr, Sch Food Engn, UNICAMP, Campinas, SP - Brazil
[2] Embrapa Meio Ambiente, Rodovia Governador Dr Adhemar Pereira de Barros, BR-13918110 Jaguariuna, SP - Brazil
[3] EMBRAPA Amazonia Ocidental, Manaus, Amazonas - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AQUACULTURE RESEARCH; v. 53, n. 4 NOV 2021.
Web of Science Citations: 0
Abstract

The therapeutic efficacy of different doses of albendazole (ABZ) in the treatment of infection by acanthocephalan (Neoechinorhynchus buttnerae) in tambaqui (Colossoma macropomum) was evaluated. The bioaccumulation of ABZ and its main metabolites in the target tissue (muscle plus skin in natural proportions) was also evaluated. The fish received a daily dose of 10, 20 or 30 mg ABZ kg(-1) bw via medicated feed for 34 days. Incorporation of ABZ in the fish feed was performed by coating with ethyl cellulose (EC) (0.75% w/w). The quantitation of ABZ residues and its metabolites in the target tissue was done using a validated ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analytical method. In relation with the therapeutic efficacy, no statistically difference was found between the treated groups. The total residue (sum of ABZ residues and its metabolites) in the target tissue at steady-state was significantly higher for the high dose. Biomagnification factors in all treatments were of low values, indicating that ABZ and its metabolites do not offer the risk of bioaccumulation in the target tissue. Thus, ABZ dose of 10 mg kg(-1) bw is recommend. However, the effect of feed coating on treatment effectiveness and bioaccumulation of albendazole relative to an uncoated feed, and joint therapeutic studies of ABZ with anthelmintic natural products are recommended to be conducted. (AU)

FAPESP's process: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
Grantee:Felix Guillermo Reyes Reyes
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE