Genome-wide association study between copy number variation regions and carcass- and meat-quality traits in Nellore cattle

Autor(es):Mostrar menos -

Berton, Mariana Piatto ^[1] ; de Antunes Lemos, Marcos Vinicius ^[1] ; Seleguim Chud, Tatiane Cristina ^[2] ; Bonvino Stafuzza, Nedenia ^[1] ; Kluska, Sabrina ^[1] ; Amorim, Sabrina Thaise ^[1] ; Silva Ferlin Lopes, Lucas ^[1] ; Cravo Pereira, Angelica Simone ^[3] ; Bickhart, Derek ^{[4, 5]} ; Liu, George ^{[4, 5]} ; Galvao de Albuquerque, Lucia ^[1] ; Baldi, Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Dept Zootecnia, Fac Ciencias Agr & Vet, Via Acesso Prof Paulo Donato Castellane, BR-14884900 Jaboticabal, SP - Brazil

^[2] Univ Guelph, Ctr Genet Improvement Livestock, 50 Stone Rd East, Bldg 70, Guelph, ON N1G 2W1 - Canada

^[3] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Rua Duque Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil

^[4] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 - USA

^[5] USDA ARS, ANRI, Bovine Funct Genom Lab, Beltsville, MD 20705 - USA

• Tipo de documento: Artigo Científico
• Fonte: ANIMAL PRODUCTION SCIENCE; v. 61, n. 8, p. 731-744, 2021.
• Citações Web of Science: 1

Resumo

Context. Indicine breeds are the main source of beef products in tropical and subtropical regions. However, genetic improvement for carcass- and meat-quality traits in zebu cattle have been limited and genomics studies concerning structural variations that influence these traits are essential. Aim. The aim of this study was to perform a genome-wide association study between copy number variation regions (CNVRs) and carcass- and meat quality-traits in Nellore cattle. Methods. In total, 3794 animals, males and females included, were genotyped using a 777 962 single-nucleotide polymorphism platform of BovineHD BeadChip (777k; Illumina Inc.). Of these, 1751 Nellore bulls were slaughtered at 24 months of age for further carcass beef analysis. The following traits were studied: beef tenderness, marbling, rib-eye area, backfat thickness and meat colour (lightness, redness and yellowness). The CNV detection was conducted through PennCNV software. The association analyses were performed using CNVRuler software. Key results. Several identified genomic regions were linked to quantitative trait loci associated with fat deposition (FABP7) and lipid metabolism (PPARA; PLA2 family; BCHE), extracellular matrix (INS; COL10A1), contraction (SLC34A3; TRDN) and muscle development (CAPZP). The gene-enrichment analyses highlighted biological mechanisms directly related to the metabolism and synthesis of lipids and fatty acids. Conclusions. The large number of potential candidate genes identified within the CNVRs, as well as the functions and pathways identified, should help better elucidate the genetic mechanisms involved in the expression of beef and carcass traits in Nellore cattle. Several CNVRs harboured genes that might have a functional impact to improve the beef and carcass traits. Implications. The results obtained contribute to upgrade the sensorial and organoleptic attributes of Nellore cattle and make feasible the genetic improvement of carcass- and meat-quality traits. (AU)

• Processo FAPESP: 09/16118-5 - Ferramentas genômicas no melhoramento genético de características de importância econômica direta em bovinos da raça Nelore
• Beneficiário: Lucia Galvão de Albuquerque
• Modalidade de apoio: Auxílio à Pesquisa - Temático