Hashtag bone: detrimental effects on bone contrast with metabolic benefits one and five years after Roux-en-Y gastric bypass

Autor(es)

Alencar, M. A. V. S. D. ^[1] ; de Araujo, I. M. ^[1] ; Parreiras-E-Silva, L. T. ^[1] ; Nogueira-Barbosa, M. H. ^[2] ; Salgado Jr, W. ; Elias Jr, J. ; Salmon, C. E. G. ^[3] ; de Paula, F. J. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med Interna, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Imagens Med Hematol & Oncol Clin, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Fis, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 54, n. 12 2021.
• Citações Web of Science: 0

Resumo

Bone loss is a potential adverse consequence of rapid and sustained weight loss after bariatric surgery. The aim of the present study was to evaluate the bone mass, body fat distribution, and metabolic parameters in women submitted to Roux-en-Y gastric bypass (RYGB). The study included the following three groups: one group of lean women (control [C] group) and two groups of obese women, one evaluated one year (B1) and the other five years (B5) after RYGB. Dual-energy X-ray absorptiometry and magnetic resonance imaging were used to determine bone mineral density (BMD; lumbar spine, total hip, and femoral neck) and abdominal fat content (subcutaneous [SAT] and visceral [VAT] adipose tissues, and intrahepatic lipids [IHL]). The BMD/body mass index ratio was lower in the B5 compared with the C group at all sites. Serum C-terminal telopeptide of type I collagen (CTX) levels were higher in the B1 and B5 groups compared with the C group. Individuals submitted to RYGB showed greater SAT but similar VAT and IHL values compared with those in the C group. However, the B5 group had higher mean parathyroid hormone levels compared with the other two groups. Individuals submitted to RYGB presented increased levels of CTX and low BMD for body weight than those in the C group, suggesting that bone catabolism is a persistent alteration associated with RYGB. In conclusion, the long-lasting metabolic benefits obtained with RYGB in obesity are counterbalanced by a persistent catabolic effect of the procedure on bone and mineral metabolism. (AU)

• Processo FAPESP: 16/18574-1 - Aplicação da ressonância magnética para estudo quantitativo da microarquitetura óssea e sua relação com o acúmulo de gordura muscular e óssea no diabetes mellitus tipo 2
• Beneficiário: Iana Mizumukai de Araujo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/18071-5 - Homeostase hidroeletrolítica e energética: do metabolismo celular aos sistemas endócrinos em diferentes fases do desenvolvimento
• Beneficiário: Lucila Leico Kagohara Elias
• Modalidade de apoio: Auxílio à Pesquisa - Temático