Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country

Autor(es)

Suemoto, Claudia K. ^[1] ; Bertola, Laiss ^[1] ; Grinberg, Lea T. ^{[2, 3]} ; Leite, Renata E. P. ^[3] ; Rodriguez, Roberta D. ^[4] ; Santana, Pedro H. ^[1] ; Pasqualucci, Carlos A. ^[3] ; Jacob-Filho, Wilson ^[1] ; Nitrini, Ricardo ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Div Geriatr, Med Sch, Sao Paulo - Brazil

^[2] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 - USA

^[3] Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Neurol, Med Sch, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ALZHEIMERS & DEMENTIA; JAN 2022.
• Citações Web of Science: 0

Resumo

Introduction Education, and less frequently occupation, has been associated with lower dementia risk in studies from high-income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low-middle-income country sample. Methods In this cross-sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR-SOB). We investigated the association of occupation complexity and education with CDR-SOB using adjusted linear regression models for age, sex, and neuropathological lesions. Results In 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR-SOB (1-4 years: beta= -0.99, 95% confidence interval {[}CI] = -1.85; -0.14, P = .02; >= 5 years: beta= -1.42, 95% CI = -2.47; -0.38, P = .008). Occupation complexity and demands were unrelated to cognition. Discussion Education, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults. (AU)

• Processo FAPESP: 16/24326-0 - Caracterização da astrogliopatia por tau no envelhecimento e em doenças neurodegenerativas
• Beneficiário: Roberta Diehl Rodriguez
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/09134-4 - A reserva cognitiva em uma população com escolaridade reduzida
• Beneficiário: Wilson Jacob Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/55318-1 - Diagnóstico nosológico de demência em população brasileira
• Beneficiário: Ricardo Nitrini
• Modalidade de apoio: Auxílio à Pesquisa - Regular