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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country

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Suemoto, Claudia K. [1] ; Bertola, Laiss [1] ; Grinberg, Lea T. [2, 3] ; Leite, Renata E. P. [3] ; Rodriguez, Roberta D. [4] ; Santana, Pedro H. [1] ; Pasqualucci, Carlos A. [3] ; Jacob-Filho, Wilson [1] ; Nitrini, Ricardo [4]
Total Authors: 9
[1] Univ Sao Paulo, Div Geriatr, Med Sch, Sao Paulo - Brazil
[2] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 - USA
[3] Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Neurol, Med Sch, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Introduction Education, and less frequently occupation, has been associated with lower dementia risk in studies from high-income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low-middle-income country sample. Methods In this cross-sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR-SOB). We investigated the association of occupation complexity and education with CDR-SOB using adjusted linear regression models for age, sex, and neuropathological lesions. Results In 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR-SOB (1-4 years: beta= -0.99, 95% confidence interval {[}CI] = -1.85; -0.14, P = .02; >= 5 years: beta= -1.42, 95% CI = -2.47; -0.38, P = .008). Occupation complexity and demands were unrelated to cognition. Discussion Education, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults. (AU)

FAPESP's process: 16/24326-0 - Characterization of tau astrogliopathy on aging and neurodegenerative diseases
Grantee:Roberta Diehl Rodriguez
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 09/09134-4 - The cognitive reserve in a population with low educational attainment
Grantee:Wilson Jacob Filho
Support type: Regular Research Grants
FAPESP's process: 06/55318-1 - Nosological diagnosis of dementia in a Brazilian population
Grantee:Ricardo Nitrini
Support type: Regular Research Grants