The cognitive reserve in a population with low educational attainment

• Grant number: 09/09134-4
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2009
• End date: July 31, 2011
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Wilson Jacob Filho
• Grantee: Wilson Jacob Filho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The neuritic plaques and the neurofibrillary tamgles are the main neuropathological findings in Alzheimer's disease. Nevertheless, these findings can be found in individuals with normal cognition, as well as in dementia patients with the same distribution. It is a matter of debate if these individuals harbor a cognitive reserve protecting them from Alzheimer's disease symptoms and what is the role of educational attainment over this reserve. The current study intends to identify the individuals with pre-symptomatic Alzheimer's disease and to investigate the possible protective role of education towards dementia. From the Brazilian Brain Bank of University of São Paulo, 150 elderly individuals with normal cognition and other 50 dementia patients will be selected. Clinical data will be gathered through a structured interview and scales for cognitive evaluation (CDR and IQCODE), conducted with a knowledgeable informant. Neuropathologic analysis will be conducted through imunohistochemistry techniques and cases will be evaluated through the Braak and Braak staging and the CERAD criteria. The groups will be analyzed: individuals without cognitive symptoms and neuropathological findings, patients with dementia caused by Alzheimer's disease and the group with pre-symptomatic Alzheimer's disease. Education will be compared among the three groups and the comparison will be controlled by age, gender and economical level. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SUEMOTO, CLAUDIA K.; FERRETTI-REBUSTINI, RENATA E. L.; RODRIGUEZ, ROBERTA D.; LEITE, RENATA E. P.; SOTERIO, LUCIANA; BRUCKI, SONIA M. D.; SPERA, RAPHAEL R.; CIPPICIANI, TARCILA M.; FARFEL, JOSE M.; CHIAVEGATTO FILHO, ALEXANDRE; et al. Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study. PLOS MEDICINE, v. 14, n. 3, MAR 2017. (09/09134-4, 12/07526-5)

SUEMOTO, CLAUDIA K.; LEITE, RENATA E. P.; FERRETTI-REBUSTINI, RENATA E. L.; RODRIGUEZ, ROBERTA D.; NITRINI, RICARDO; PASQUALUCCI, CARLOS A.; JACOB-FILHO, WILSON; GRINBERG, LEA T.. Neuropathological lesions in the very old: results from a large Brazilian autopsy study. Brain Pathology, v. 29, n. 6, p. 771-781, NOV 2019. (06/55318-1, 09/09134-4)

PARADELA, REGINA SILVA; FARIAS-ITAO, DANIELA SOUZA; LEITE, RENATA E. P.; PASQUALUCCI, CARLOS A.; GRINBERG, LEA T.; NASLAVSKY, MICHEL SATYA; ZATZ, MAYANA; NITRINI, RICARDO; JACOB-FILHO, WILSON; SUEMOTO, CLAUDIA KIMIE. Apolipoprotein E 62 allele is associated with lower risk of carotid artery obstruction in a population-based autopsy study. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, v. 32, n. 9, p. 6-pg., 2023-09-01. (09/09134-4, 16/24326-0, 17/24066-1, 06/55318-1)

SUEMOTO, CLAUDIA K.; BERTOLA, LAISS; GRINBERG, LEA T.; LEITE, RENATA E. P.; RODRIGUEZ, ROBERTA D.; SANTANA, PEDRO H.; PASQUALUCCI, CARLOS A.; JACOB-FILHO, WILSON; NITRINI, RICARDO. Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country. ALZHEIMERS & DEMENTIA, JAN 2022. (16/24326-0, 09/09134-4, 06/55318-1)

NELSON, PETER T.; BRAYNE, CAROL; FLANAGAN, MARGARET E.; ABNER, ERIN L.; AGRAWAL, SONAL; ATTEMS, JOHANNES; CASTELLANI, RUDOLPH J.; CORRADA, MARIA M.; CYKOWSKI, MATTHEW D.; DI, JING; et al. Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. ACTA NEUROPATHOLOGICA, v. 144, n. 1, p. 18-pg., 2022-06-13. (09/09134-4, 06/55318-1, 16/24326-0)

NASLAVSKY, MICHEL SATYA; SUEMOTO, CLAUDIA K.; BRITO, LUCIANO ABREU; SCLIAR, MARILIA OLIVEIRA; FERRETTI-REBUSTINI, RENATA ELOAH; RODRIGUEZ, ROBERTA DIEHL; LEITE, RENATA E. P.; ARAUJO, NATHALIA MATTA; BORDA, VICTOR; TARAZONA-SANTOS, EDUARDO; et al. Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample. MOLECULAR PSYCHIATRY, v. 27, n. 11, p. 9-pg., 2022-09-07. (16/24326-0, 13/08028-1, 06/55318-1, 18/16626-0, 14/50931-3, 09/09134-4)

SUEMOTO, CLAUDIA K.; FERRETTI-REBUSTINI, RENATA E. L.; RODRIGUEZ, ROBERTA D.; LEITE, RENATA E. P.; SOTERIO, LUCIANA; BRUCKI, SONIA M. D.; SPERA, RAPHAEL R.; CIPPICIANI, TARCILA M.; FARFEL, JOSE M.; CHIAVEGATTO FILHO, ALEXANDRE; et al. Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study. PLOS MEDICINE, v. 14, n. 3, p. 22-pg., 2017-03-01. (12/07526-5, 09/09134-4)