n sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Patholog

Autor(es):Mostrar menos -

Yates, Abi G. ^{[1, 2]} ; Pink, Ryan C. ^[3] ; Erdbrugger, Uta ^[4] ; Siljander, Pia R-M. ^[5] ; Dellar, Elizabeth R. ^[3] ; Pantazi, Paschalia ^[3] ; Akbar, Naveed ^[6] ; Cooke, William R. ^[7] ; Vatish, Manu ^[7] ; Dias-Neto, Emmanuel ^{[8, 9]} ; Anthony, Daniel C. ^[1] ; Couch, Yvonne ^[10]

Afiliação do(s) autor(es)

^[1] Univ Oxford, Dept Pharmacol, Oxford - England

^[2] Univ Queensland, Sch Biomed Sci, Fac Med, St Lucia, Qld - Australia

^[3] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Oxford - England

^[4] Univ Virginia, Dept Med, Div Nephrol, Charlottesville, VA - USA

^[5] Univ Helsinki, Fac Biol & Environm Sci, Mol & Integrat Biosci Res Programme, Helsinki - Finland

^[6] Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford - England

^[7] John Radcliffe Hosp, Nuffield Dept Womens & Reprod Hlth, Oxford - England

^[8] AC Camargo Canc Ctr, Lab Med Genom, Sao Paulo - Brazil

^[9] Sao Paulo Med Sch, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil

^[10] Univ Oxford, Radcliffe Dept Med, Acute Stroke Programme, Oxford - England

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF EXTRACELLULAR VESICLES; v. 11, n. 1 JAN 2022.
• Citações Web of Science: 0

Resumo

It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of most, if not all, normal physiological systems. However, the majority of our knowledge about EV signalling has come from studying them in disease. Indeed, EVs have consistently been associated with propagating disease pathophysiology. The analysis of EVs in biofluids, obtained in the clinic, has been an essential of the work to improve our understanding of their role in disease. However, to interfere with EV signalling for therapeutic gain, a more fundamental understanding of the mechanisms by which they contribute to pathogenic processes is required. Only by discovering how the EV populations in different biofluids change-size, number, and physicochemical composition-in clinical samples, may we then begin to unravel their functional roles in translational models in vitro and in vivo, which can then feedback to the clinic. In Part II of this review series, the functional role of EVs in pathology and disease will be discussed, with a focus on in vivo evidence and their potential to be used as both biomarkers and points of therapeutic intervention. (AU)

• Processo FAPESP: 14/26897-0 - Epidemiologia e genômica de adenocarcinomas gástricos no Brasil
• Beneficiário: Emmanuel Dias-Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/50257-3 - Extracellular vesicles and non-cellular RNA: roles in health and neglected tropical diseases | São Paulo - SP
• Beneficiário: Emmanuel Dias-Neto
• Modalidade de apoio: Auxílio Organização - Reunião Científica
• Processo FAPESP: 11/09172-3 - Avaliação de micropartículas circulantes em pacientes com câncer de mama ductal invasivo Her2+ e sua possível relação com a agressividade tumoral
• Beneficiário: Emmanuel Dias-Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular