ammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactatio

Autor(es)

Rocha Ruiz, Thalles Fernando ^[1] ; Colleta, Simone J. ^[1] ; Leonel, Ellen C. R. ^[2] ; Taboga, Sebastiao Roberto ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Inst Biosci Humanities & Exact Sci, Dept Biol, UNESP, Sao Jose Do Rio Preto, SP - Brazil

^[2] Fed Univ Goias UFG, Inst Biol Sci ICB 3, Dept Histol Embryol & Cell Biol, Campus Samambaia, Goiania, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Endocrine-Related Cancer; v. 28, n. 11, p. 715-730, NOV 1 2021.
• Citações Web of Science: 0

Resumo

Compounds that trigger breast cancer onset and establishment are of great interest in biological research. Endocrine disruptors are relevant because they initiate carcinogenesis by changing endocrine pathways. Bisphenol A (BPA), as a ubiquitous xenoestrogen, is largely associated with dysfunctions in the female reproductive system and associated organs. This study proposes an investigation of the mammary gland (MG) in aged Mongolian gerbil (Meriones unguiculatus) mothers after their exposure to BPA in two windows of morphophysiological plasticity: pregnancy and lactation. A low dose (50 mu g/kg) and a high dose (5000 mu g/kg) of BPA were considered, and results showed few differences between them. As expected, we observed contrasts among control and BPA-exposed MG. The control groups presented a regressive phase with high apoptotic activity and elastic stroma. However, BPA damaged mammary tissue and provoked multifocal carcinoma development supported by an apparent epithelial-mesenchymal transition (EMT) and reactive stroma establishment. BPA remodeled stromal fibers deposition and enhanced the recruitment of tumor-associated cells, contributing to a tumoral microenvironment. Overexpression of TGF-beta 1 was induced by BPA in the epithelial compartment of exposed MG, and increased expression of metalloproteinases (MMP-2, MMP-3, MMP-9) was present in carcinoma cells. In conclusion, exposure of mothers to BPA during the gestational/lactational window of susceptibility leads to carcinogenic impacts with aging. (AU)

• Processo FAPESP: 20/01240-9 - Efeitos tardios da exposição ao bisfenol A na mama de fêmeas de gerbilos durante o período gestacional e lactacional
• Beneficiário: Thalles Fernando Rocha Ruiz
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/23383-6 - Repercussões histopatológicas da ação dos desreguladores endócrinos bisfienol-A e 17-beta-estradiol sobre glândulas mamárias e próstata feminina do Gerbilo da Mongólia e suas relações com a carcinogênese quimicamente induzida pelo MNU
• Beneficiário: Sebastião Roberto Taboga
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/00160-1 - Efeitos da exposição materna ao bisfenol A sobre próstata de gerbilos (Meriones unguiculatus) adultos e senescentes
• Beneficiário: Simone Jacovaci Colleta
• Modalidade de apoio: Bolsas no Brasil - Doutorado