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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactatio

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Author(s):
Rocha Ruiz, Thalles Fernando [1] ; Colleta, Simone J. [1] ; Leonel, Ellen C. R. [2] ; Taboga, Sebastiao Roberto [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, Inst Biosci Humanities & Exact Sci, Dept Biol, UNESP, Sao Jose Do Rio Preto, SP - Brazil
[2] Fed Univ Goias UFG, Inst Biol Sci ICB 3, Dept Histol Embryol & Cell Biol, Campus Samambaia, Goiania, Go - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Endocrine-Related Cancer; v. 28, n. 11, p. 715-730, NOV 1 2021.
Web of Science Citations: 0
Abstract

Compounds that trigger breast cancer onset and establishment are of great interest in biological research. Endocrine disruptors are relevant because they initiate carcinogenesis by changing endocrine pathways. Bisphenol A (BPA), as a ubiquitous xenoestrogen, is largely associated with dysfunctions in the female reproductive system and associated organs. This study proposes an investigation of the mammary gland (MG) in aged Mongolian gerbil (Meriones unguiculatus) mothers after their exposure to BPA in two windows of morphophysiological plasticity: pregnancy and lactation. A low dose (50 mu g/kg) and a high dose (5000 mu g/kg) of BPA were considered, and results showed few differences between them. As expected, we observed contrasts among control and BPA-exposed MG. The control groups presented a regressive phase with high apoptotic activity and elastic stroma. However, BPA damaged mammary tissue and provoked multifocal carcinoma development supported by an apparent epithelial-mesenchymal transition (EMT) and reactive stroma establishment. BPA remodeled stromal fibers deposition and enhanced the recruitment of tumor-associated cells, contributing to a tumoral microenvironment. Overexpression of TGF-beta 1 was induced by BPA in the epithelial compartment of exposed MG, and increased expression of metalloproteinases (MMP-2, MMP-3, MMP-9) was present in carcinoma cells. In conclusion, exposure of mothers to BPA during the gestational/lactational window of susceptibility leads to carcinogenic impacts with aging. (AU)

FAPESP's process: 20/01240-9 - Late effects of bisphenol A exposure in the mammary gland of female gerbils during pregnancy and lactation
Grantee:Thalles Fernando Rocha Ruiz
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/23383-6 - Histopathological repercussions of the endocrine disrupters bisfienol-A and 17-beta-oestradiol on mammary glands and female prostate of the Mongolian Gerbil and their relatioships with the chemically induced carcinogenesis by MNU
Grantee:Sebastião Roberto Taboga
Support Opportunities: Regular Research Grants
FAPESP's process: 20/00160-1 - Effects of maternal exposure to bisphenol A on adult and senescent gerbil (Meriones unguiculatus) prostate
Grantee:Simone Jacovaci Colleta
Support Opportunities: Scholarships in Brazil - Doctorate