and T Lymphocyte Densities Remain Stable With Age in Human Corte

Autor(es)

Berry, Kacey ^{[1, 2]} ; Farias-Itao, Daniela S. ^[3] ; Grinberg, Lea T. ^{[4, 2]} ; Plowey, Edward D. ^[5] ; Schneider, Julie A. ^[6] ; Rodriguez, Roberta D. ^{[7, 8]} ; Suemoto, Claudia K. ^[3] ; Buckwalter, Marion S. ^{[1, 9]}

Afiliação do(s) autor(es)

^[1] Stanford Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 - USA

^[2] Univ Calif San Francisco, Sch Med, Dept Neurol & Pathol, San Francisco, CA - USA

^[3] Univ Sao Paulo, Div Geriatr, Med Sch, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo - Brazil

^[5] Stanford Sch Med, Dept Pathol, Stanford, CA 94305 - USA

^[6] Rush Univ, Dept Pathol, Med Ctr, Chicago, IL - USA

^[7] Univ Sao Paulo, Dept Neurol, Med Sch, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Biobank Aging Studies, Med Sch, Sao Paulo - Brazil

^[9] Stanford Sch Med, Dept Neurosurg, Stanford, CA 94305 - USA

• Tipo de documento: Artigo Científico
• Fonte: ASN NEURO; v. 13, MAY 2021.
• Citações Web of Science: 0

Resumo

One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes traffic through the human brain and reside there in small numbers, but it is unknown how this changes with age. Thus we investigated whether B- and T-lymphocyte numbers change with age in the normal human brain. We examined 16 human subjects in a pilot study and then 40 human subjects from a single brain bank, ranging in age from 44-96 years old, using rigorous criteria for defining neuropathological changes due to age alone. We immunostained post-mortem cortical tissue for B- and T-lymphocytes using antibodies to CD20 and CD3, respectively. We quantified cell density and made a qualitative assessment of cell location in cortical brain sections, and reviewed prior studies. We report that density and location of both B- and T-lymphocytes do not change with age in the normal human cortex. Solitary B-lymphocytes were found equally in intravascular, perivascular, and parenchymal locations, while T-lymphocytes appeared primarily in perivascular clusters. Thus, any change in number or location of lymphocytes in an aging brain may indicate disease rather than normal aging. (AU)

• Processo FAPESP: 17/24066-1 - Caracterização do perfil da resposta inflamatória no tecido adiposo perivascular associada à doença arterial coronariana: um estudo de autópsia
• Beneficiário: Daniela Souza Farias Itao
• Modalidade de apoio: Bolsas no Brasil - Doutorado