enetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statin

Autor(es)

Watanabe, Ligia Moriguchi ^[1] ; Bueno, Ana C. ^[2] ; de Lima, Livia F. ^[1] ; Ferraz-Bannitz, Rafael ^[1] ; Dessordi, Renata ^[3] ; Guimaraes, Mariana P. ^[1] ; Foss-Freitas, Maria C. ^[1] ; Barbosa, Fernando ^[4] ; Navarro, Anderson M. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Pediat, Ribeirao Preto, SP - Brazil

^[3] Sao Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, UNESP, Araraquara, SP - Brazil

^[4] Univ Sao Paulo FCFRP USP, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin & Toxicol Anal & Bromatol, Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Hlth Sci, Div Nutr & Metab, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF NUTRITION; v. 127, n. 5, p. 679-686, MAR 14 2022.
• Citações Web of Science: 1

Resumo

Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirao Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention. (AU)

• Processo FAPESP: 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua
• Beneficiário: Fernando Barbosa Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/05677-7 - Efeito do consumo da castanha-do-brasil (Bertholetia excelsa H.B.K.) sobre selenocompostos no uso crônico de estatinas
• Beneficiário: Lígia Moriguchi Watanabe
• Modalidade de apoio: Bolsas no Brasil - Doutorado