Salivary gland cancer in the setting of tumor microenvironment: Translational routes for therapy

Autor(es):Mostrar menos -

Lavareze, Luccas ; Scarini, Jo ao Figueira ; de Lima-Souza, Reydson Alcides ; Emerick, Carolina ; de Sa, Raisa Sales ; Aquino, Iara Goncalves ; Fernandes, Patricia Maria ; Goncalves, Mayara Trevizol ; Helms, My N. ; Altemani, Albina ; Abu Egal, Erika Said ; Mariano, Fernanda Viviane

• Tipo de documento: Artigo Científico
• Fonte: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; v. 171, p. 10-pg., 2022-03-01.

Resumo

Salivary gland carcinomas (SGC) are aggressive cancers that arise in minor and major salivary glands. Given the complexity and the multiple subtypes of this class of tumors, diagnosis and, treatment may be challenging for clinicians. Recently the tumor microenvironment, composed mainly of immune and stromal cells are been a target for treatment. Accumulating evidence indicates that cancer immunotherapies have made a significant impact on oncologic patients, however immunotherapeutic attempts in SGC have been shown limited improvement. Advances in the models that best translate aggressive SGC are needed for the development of clinical protocols grouping immunotherapies and other classes of drugs that will promote better responses in patients with advanced SGC stages. In this review, we introduced different experimental models for SGC with a focus on tumor microenvironment highlighting potential therapy applications for each model. (AU)

• Processo FAPESP: 19/06809-2 - Análise de espectrometria de massa na transformação maligna do adenoma pleomorfo. correlação de dados com expressão gênica e exoma
• Beneficiário: Reydson Alcides de Lima Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 19/09419-0 - Alterações genômicas na transformação maligna do Adenoma Pleomorfo
• Beneficiário: João Figueira Scarini
• Modalidade de apoio: Bolsas no Brasil - Doutorado