Salivary gland cancer in the setting of tumor microenvironment: Translational routes for therapy

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Lavareze, Luccas ; Scarini, Jo ao Figueira ; de Lima-Souza, Reydson Alcides ; Emerick, Carolina ; de Sa, Raisa Sales ; Aquino, Iara Goncalves ; Fernandes, Patricia Maria ; Goncalves, Mayara Trevizol ; Helms, My N. ; Altemani, Albina ; Abu Egal, Erika Said ; Mariano, Fernanda Viviane

• Document type: Journal article
• Source: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; v. 171, p. 10-pg., 2022-03-01.

Abstract

Salivary gland carcinomas (SGC) are aggressive cancers that arise in minor and major salivary glands. Given the complexity and the multiple subtypes of this class of tumors, diagnosis and, treatment may be challenging for clinicians. Recently the tumor microenvironment, composed mainly of immune and stromal cells are been a target for treatment. Accumulating evidence indicates that cancer immunotherapies have made a significant impact on oncologic patients, however immunotherapeutic attempts in SGC have been shown limited improvement. Advances in the models that best translate aggressive SGC are needed for the development of clinical protocols grouping immunotherapies and other classes of drugs that will promote better responses in patients with advanced SGC stages. In this review, we introduced different experimental models for SGC with a focus on tumor microenvironment highlighting potential therapy applications for each model. (AU)

• FAPESP's process: 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate