The complex search for the cause of gastroschisis

Autor(es)

de Freitas, Amanda Brasil ; Vieira Francisco, Rossana Pulcineli ; Hoshida, Mara Sandra ; De Oliveira, Yanca Gasparini ; Kulikowski, Leslie Domenici ; Brizot, Maria de Lourdes

• Tipo de documento: Artigo Científico
• Fonte: BIRTH DEFECTS RESEARCH; v. N/A, p. 7-pg., 2022-05-16.

Resumo

Background To reveal the complex etiology of gastroschisis through two independent cases. Cases Case 1 involves gastroschisis recurrence in a consanguineous marriage, and Case 2 concerns a fetus with gastroschisis whose mother had undergone gastroplasty. Methylation array was carried out in both cases (two fetuses with gastroschisis, their two mothers, one father from the consanguineous marriage), and in 16 controls (fetuses and their respective mothers). Conclusion The two cases presented different noninherited methylation profiles. (AU)

• Processo FAPESP: 17/17568-0 - Gastrosquise fetal: estudo do perfil epigenético
• Beneficiário: Maria de Lourdes Brizot
• Modalidade de apoio: Auxílio à Pesquisa - Regular