The complex search for the cause of gastroschisis

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Author(s):	de Freitas, Amanda Brasil ; Vieira Francisco, Rossana Pulcineli ; Hoshida, Mara Sandra ; De Oliveira, Yanca Gasparini ; Kulikowski, Leslie Domenici ; Brizot, Maria de Lourdes Total Authors: 6
Document type:	Journal article
Source:	BIRTH DEFECTS RESEARCH; v. N/A, p. 7-pg., 2022-05-16.
Abstract
Background To reveal the complex etiology of gastroschisis through two independent cases. Cases Case 1 involves gastroschisis recurrence in a consanguineous marriage, and Case 2 concerns a fetus with gastroschisis whose mother had undergone gastroplasty. Methylation array was carried out in both cases (two fetuses with gastroschisis, their two mothers, one father from the consanguineous marriage), and in 16 controls (fetuses and their respective mothers). Conclusion The two cases presented different noninherited methylation profiles. (AU)

FAPESP's process:	17/17568-0 - Fetal gastroschisis: epigenetic profile study
Grantee:	Maria de Lourdes Brizot
Support Opportunities:	Regular Research Grants