Characterization of Patients With Dermatomyositis According to Anti-Melanoma Differentiation-Associated Gene-5 Autoantibodies in Centers from 3 Latin American Countries A Cohort Study

Autor(es)

Olivo Pallo, Pablo Arturo ; Hoff, Leonardo Santos ; Pires Borges, Isabela Bruna ; Torres-Ruiz, Jiram ; Cassiano-Quezada, Fabiola ; Granel, Amelia ; Gomez, Graciela ; Pisoni, Cecilia ; Gomez, Ramiro ; Shinjo, Samuel Katsuyuki

• Tipo de documento: Artigo Científico
• Fonte: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY; v. 28, n. 2, p. 5-pg., 2022-03-01.

Resumo

Background/Objective The anti-melanoma differentiation-associated protein 5 (MDA5) autoantibodies have been associated with a high frequency of interstitial lung disease (ILD) and rapidly progressive ILD (RP-ILD) in dermatomyositis (DM) patients, mainly in Asian subjects. However, there is scarce information about these parameters in Latin American patients. Method This was a medical records review cohort study that included classic DM (CDM) and clinically amyopathic DM (CADM) patients from 3 Latin American countries (Argentina, Brazil, and Mexico). Results A total of 270 DM patients were evaluated: 25.9% with CADM and 74.1% with CDM. The overall prevalence of ILD and RP-ILD, respectively, was 70 (25.9%) and 4 (1.5%) of the 270 patients, and the distributions were comparable between patients with CDM and CADM. The anti-MDA5 was present in 31 (25.4%) of 122 CDM patients and in 17 (48.6%) of 35 CADM patients; it was not associated with presence of ILD and RP-ILD. However, anti-MDA5-positive CDM patients had significantly high frequency of "mechanic's hands," arthralgia, arthritis, and lower serum levels of creatine phosphokinase, whereas anti-MDA5-positive CADM patients had significantly high frequency of arthritis. Pulmonary infection and ILD are main causes of death in DM patients. Conclusions In the present study, the prevalence of ILD in DM patients is comparable to that described in the literature, in contrast to the very low frequency of RP-ILD. In addition, the anti-MDA5 is not associated with ILD and RP-ILD, but anti-MDA5-positive DM patients present conditions that mimic antisynthetase syndrome. Pulmonary infection and ILD were the main causes of death in our sample. (AU)

• Processo FAPESP: 19/11776-6 - Impacto e segurança da neuromodulação cerebral não-invasiva em pacientes com doenças autoimunes sistêmicas: estudo duplo cego, randomizado e placebo-controlado
• Beneficiário: Samuel Katsuyuki Shinjo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/11367-9 - Análise molecular e metabólica da Atorvastatina nos tecidos musculares de pacientes com Miopatias Autoimunes Sistêmicas
• Beneficiário: Isabela Bruna Pires Borges
• Modalidade de apoio: Bolsas no Brasil - Doutorado