Macrophages: key players in erythrocyte turnover

Autor(es)

Marina Dorigatti Borges ^[1] ; Renata Sesti-Costa ^[2]

Afiliação do(s) autor(es)

^[1] University of Campinas, UNICAMP. Hematology and Hemotherapy Center - Brasil

^[2] University of Campinas, UNICAMP. Hematology and Hemotherapy Center - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Hematology, Transfusion and Cell Therapy; v. 44, n. 4, p. 574-581, 2022-12-12.

Resumo

ABSTRACT The development of red blood cells (RBCs), or erythropoiesis, occurs in specialized niches in the bone marrow, called erythroblastic islands, composed of a central macrophage surrounded by erythroblasts at different stages of differentiation. Upon anemia or hypoxemia, erythropoiesis extends to extramedullary sites, mainly spleen and liver, a process known as stress erythropoiesis, leading to the expansion of erythroid progenitors, iron recruitment and increased production of reticulocytes and mature RBCs. Macrophages are key cells in both homeostatic and stress erythropoiesis, providing conditions for erythroid cells to survive, proliferate and differentiate. During RBCs aging and injury, macrophages play a fundamental role again, performing the clearance of these cells and recycling iron for new erythroblasts in development. Thus, macrophages are crucial components of the RBCs turnover and in this review, we aimed to cover the main known mechanisms involved in the process of birth and death of RBCs, highlighting the importance of macrophage functions in the whole RBC lifecycle. (AU)

• Processo FAPESP: 21/05191-5 - Células dendríticas na anemia falciforme: mecanismos moleculares envolvidos na regulação da inflamação e da resposta imune adaptativa
• Beneficiário: Renata Sesti Costa
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 19/09704-7 - Células dendríticas na Anemia Falciforme: mecanismos moleculares envolvidos na regulação da inflamação e da resposta imune adaptativa
• Beneficiário: Renata Sesti Costa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores