Are the 50's, the transition decade, in choroid plexus aging?

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Tahira, Ana ; Marques, Fernanda ; Lisboa, Bianca ; Feltrin, Arthur ; Barbosa, Andre ; de Oliveira, Katia Cristina ; de Braganca Pereira, Carlos Alberto ; Leite, Renata ; Grinberg, Lea ; Suemoto, Claudia ; de Lucena Ferretti-Rebustini, Renata Eloah ; Pasqualucci, Carlos Augusto ; Jacob-Filho, Wilson ; Brentani, Helena ; Palha, Joana Almeida

• Tipo de documento: Artigo Científico
• Fonte: GEROSCIENCE; v. 43, n. 1, p. 13-pg., 2021-02-12.

Resumo

The choroid plexus (CP) is an important structure for the brain. Besides its major role in the production of cerebrospinal fluid (CSF), it conveys signals originating from the brain, and from the circulatory system, shaping brain function in health and in pathology. Previous studies in rodents have revealed altered transcriptome both during aging and in various diseases of the central nervous system, including Alzheimer's disease. In the present study, a high-throughput sequencing of the CP transcriptome was performed in postmortem samples of clinically healthy individuals aged 50's through 80's. The data shows an age-related profile, with the main changes occurring in the transition from the 50's to the 60's, stabilizing thereafter. Specifically, neuronal and membrane functions distinguish the transcriptome between the 50's and the 60's, while neuronal and axon development and extracellular structure organization differentiate the 50's from the 70's. These findings suggest that changes in the CP transcriptome occur early in the aging process. Future studies will unravel whether these relate with processes occurring in late- onset brain diseases. (AU)

• Processo FAPESP: 14/10488-3 - Comparação de métodos de priorização de genes associados a transtornos do neurodesenvolvimento
• Beneficiário: Arthur Sant'Anna Feltrin
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/00041-1 - Estudo de coexpressão de genes do cromossomo Y e genes autossômicos e sua relação com o transtorno do espectro autista (TEA)
• Beneficiário: Ana Carolina Tahira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/14658-2 - Variação no número de cópias no genoma de pacientes com transtorno obsessivo compulsivo e pacientes com transtornos do espectro autista com interesses restritos e comportamentos repetitivos
• Beneficiário: Helena Paula Brentani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/00591-1 - Estudos de redes de co-expressão gênica do córtex orbitofrontal e estriado (estudo post-mortem) de indivíduos portadores de TOC e controles
• Beneficiário: Bianca Cristina Garcia Lisboa
• Modalidade de apoio: Bolsas no Brasil - Doutorado