| Texto completo | |
| Autor(es): Mostrar menos - |
Fernandes, Alan L.
;
Murai, Igor H.
;
Reis, Bruna Z.
;
Sales, Lucas P.
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Santos, Mayara D.
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Pinto, Ana J.
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Goessler, Karla F.
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Duran, Camila S. C.
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Silva, Carla B. R.
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Franco, Andre S.
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Macedo, Marina B.
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Dalmolin, Henrique H. H.
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Baggio, Janaina
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Balbi, Guilherme G. M.
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Antonangelo, Leila
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Caparbo, Valeria F.
;
Gualano, Bruno
;
Pereira, Rosa M. R.
Número total de Autores: 18
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| Tipo de documento: | Artigo Científico |
| Fonte: | AMERICAN JOURNAL OF CLINICAL NUTRITION; v. 115, n. 3, p. 9-pg., 2022-03-04. |
| Resumo | |
Background: The modulating effect of vitamin D on cytokine concentrations in severe coronavirus disease 2019 (COVID-19) remains unknown. Objectives: We aimed to investigate the effect of a single high dose of vitamin D-3 on cytokincs, chemokines, and growth factor in hospitalized patients with moderate to severe COVID-19. Methods: This is a post hoc, ancillary, and exploratory analysis from a multicenter, double-blind. placebo-controlled, randomized clinical trial. Patients with moderate to severe COVID-19 were recruited from 2 hospitals in Sao Paulo. Brazil. Of 240 randomly assigned patients, 200 were assessed in this study and randomly assigned to receive a single oral dose of 200,000 IU vitamin D-3 (n = 101) or placebo (n = 99). The primary outcome was hospital length of stay, which has been published in our previous study. The prespecified secondary outcomes were serum concentrations of IL-1 beta, IL-6, IL-10. INF-alpha. and 25-hydroxyvitamin D. The post hoc exploratory secondary outcomes were IL-4, IL-12p70. IL-17A, IFN-gamma. granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-8, IFN-inducible protein-10 (IP-10), macrophage inflammatory protein-1 beta (MIP-1 beta), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and leukocyte count. Generalized estimating equations for repeated measures, with Bonferroni's adjustment, were used for testing all outcomes. Results: The study included 200 patients with a mean +/- SD age of 55.5 +/- 14.3 y and BMI of 32.2 +/- 7.1 kg/m(2), of which 109 (54.5%) were male. GM-CSF concentrations showed a significant group-by-time interaction effect (P = 0.04). although the between-group difference at postintervention after Bonferroni's adjustment was not significant. No significant effects were observed for the other outcomes. Conclusions: The findings do not support the use of a single dose of 200,000 IU vitamin D-3, compared with placebo, for the improvement of cytokines, chemokines, and growth factor in hospitalized patients with moderate to severe COVID-19. (AU) | |
| Processo FAPESP: | 20/11102-2 - Suplementação com vitamina D em pacientes com COVID-19: ensaio clínico, randomizado, duplo-cego e controlado por placebo |
| Beneficiário: | Alan Lins Fernandes |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/18039-7 - Reduzindo tempo sedentário em pacientes bariátricos: um estudo controlado e randomizado |
| Beneficiário: | Karla Fabiana Goessler |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/24782-4 - Comparação dos mecanismos de perda óssea em pacientes submetidos à derivação gástrica em Y de Roux ou gastrectomia vertical |
| Beneficiário: | Igor Hisashi Murai |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 20/05752-4 - Suplementação com vitamina D em pacientes com COVID-19: ensaio clínico, randomizado, duplo-cego e controlado por placebo |
| Beneficiário: | Rosa Maria Rodrigues Pereira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |