Antibacterial and antifungal activities in vitro of a novel silver(I) complex with sulfadoxine-salicylaldehyde Schiff base

Autor(es)

Oliveira, Igor Santos ; Manzano, Carlos Marrote ; Nakahata, Douglas Hideki ; Santiago, Mariana Brentini ; Silva, Nagela Bernadelli Sousa ; Martins, Carlos Henrique Gomes ; Respindula, Fernando Pimentel ; Pereira, Douglas Henrique ; Corbi, Pedro Paulo

• Tipo de documento: Artigo Científico
• Fonte: Polyhedron; v. 225, p. 12-pg., 2022-08-04.

Resumo

Skin wound infections can be considered one of the most common causes of death in burned patients. The raising reports of multidrug resistant microorganisms reveals a complicated condition for the treatment of burn wound injuries, establishing urgency in the development of novel antimicrobial agents. Considering this scenario, the present work describes the synthesis, antibacterial and antifungal activities of a sulfadoxine-salicylaldehyde Schiff base (SFX-SL), and of its novel dimeric silver(I) complex (AgSFX-SL). Elemental analysis indicated a 1:1 metal:ligand molar composition for the AgSFX-SL complex, with the minimum formula AgC19H17N4O5S. Mass spectrometric (HRMS) data reveal the existence of dimeric species of the complex in solution. Infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopic studies suggest coordination of the Schiff base to silver(I) by the nitrogen and oxygen atoms of the sulfonamide group. The structure of the SFX-SL Schiff base was determined by single crystal X-ray diffraction. Molecular modeling confirms the proposition of a dimeric structure for the AgSFX-SL complex as early indicated by mass spectrometric data. The AgSFX-SL complex showed an effective antimicrobial activity over pathogens including Gram-positive Staphylococcus aureus (multidrug resistant), S. epidermidis, Cutibacterium acnes, and Gram-negative Pseudomonas aeruginosa and Bur-kholderia cepacia, with minimum inhibitory concentration (MIC) values in the range 12.0-48.0 mu mol.L- 1. Additionally, the AgSFX-SL complex was active against Candida albicans with a MIC value of 2.8 mu mol.L- 1. Electrophoresis assays showed that the AgSFX-SL complex does not interact with protein models lysozyme and bovine serum albumin (BSA). (AU)

• Processo FAPESP: 17/25995-6 - Novos complexos metálicos de Ag(I), Pd(II) e Pt(II) com ligantes utilizados no tratamento da Tuberculose: síntese e avaliação in vitro das atividades antimicrobiana e antiproliferativa
• Beneficiário: Carlos Marrote Manzano
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/12062-4 - Síntese, caracterização e estudos de interação com biomoléculas de complexos metálicos contendo ligantes biologicamente ativos: uma estratégia na preparação de novos agentes com atividades antibacterianas e antivirais
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/08717-8 - Síntese de complexos de cobre, prata e ouro envolvendo análogos de nucleotídeos na busca por novas alternativas para o tratamento do câncer de ovário
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular