Green Extraction Process of Food Grade C-phycocyanin: Biological Effects and Metabolic Study in Mice

Autor(es)

Fratelli, Camilly ; Burck, Monize ; Silva-Neto, Artur Francisco ; Oyama, Lila Missae ; De Rosso, Veridiana Vera ; Cavalcante Braga, Anna Rafaela

• Tipo de documento: Artigo Científico
• Fonte: PROCESSES; v. 10, n. 9, p. 17-pg., 2022-09-01.

Resumo

This study aimed to evaluate different parameters in the green process of organic Spirulina biomass (SB) C-phycocyanin (C-PC) extraction to understand the impact on weight and oral glucose tolerance of C-PC extract in Swiss mice fed with a high-fat diet (HFD). The proximate composition and antioxidant activity were analyzed in Spirulina by-products: SB, C-PC, and Remaining biomass (RB). The protein content on a dry basis was 52.05% in SB and 61.16% in RB and 118.97 mu g/g in C-PC. The antioxidant activity was equal for SB and C-PC but higher than RB. However, RB can be considered a promising ingredient, promoting the sustainable use of the whole SB. Swiss mice were distributed in five groups: control diet (CD), HFD, HFD plus Spirulina biomass (HFDS), HFD plus C-PC (HFDC), and HFD plus remaining biomass (HFDR). HFDS increased the delta weight of the animals and showed glucose intolerance compared to the CD and HFDC groups. The results demonstrated that the supplementation of 500 mg/kg of body weight of SB in the HFDS group did not show antiobesogenic potential with an HFD, but it is essential to conduct further studies to bring other interesting responses regarding C-PC biological in vivo effects. (AU)

• Processo FAPESP: 20/06732-7 - Estudo panorâmico para o uso da biomassa de Spirulina: da extração de compostos bioativos ao seu encapsulamento e aplicação
• Beneficiário: Anna Rafaela Cavalcante Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular