| Texto completo | |
| Autor(es): |
Garcia, Cindy Ruiz
;
Ueda, Thais Yumi
;
da Silva, Rafaela Alves
;
Cano, Isadora Prado
;
Saldanha, Luiz Leonardo
;
Dokkedal, Anne Ligia
;
Porto, Vinicius Carvalho
;
Urban, Vanessa Migliorini
;
Neppelenbroek, Karin Hermana
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | THERAPEUTIC DELIVERY; v. 13, n. 3, p. 10-pg., 2022-02-23. |
| Resumo | |
Aim: This study investigated the effect of denture liners surface modification with Equisetum giganteum (EG) and Punica granatum (PG) on Candida albicans biofilm inhibition supposing its usage as a sustained-release therapeutical delivery system for Candida-associated denture stomatitis. Materials & methods: C. albicans biofilm (SC5314 or ATCC 90028) was formed on soft liners superficially modified by a primer mixed to drugs at minimum inhibitory concentrations (0.100 g for EG and PG or 0.016 g for nystatin per ml of primer). After 24 h, 7 or 14 days, antibiofilm activity was evaluated by colony-forming unit counts. Results: Not all groups were equi-efficient to nystatin after 24 h and 7 days. After 14 days, EG and PG efficacies were not different from nystatin (almost 100% inhibition). Conclusion: The proposed protocol presents a promising option to allopathic drugs for Candida-associated denture stomatitis treatment. (AU) | |
| Processo FAPESP: | 17/07314-1 - Avaliação clínica da adição de antifúngicos a reembasador resiliente temporário no tratamento da estomatite protética |
| Beneficiário: | Karin Hermana Neppelenbroek |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/08702-2 - Aplicação superficial de agentes fitoterápicos em materiais resilientes temporários para base de prótese: efeito sobre o biofilme de Candida albicans |
| Beneficiário: | Thaís Yumi Ueda |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |