Maternal plasma transforming growth factor-β1 (TGF-β1) and newborn size: the Araraquara Cohort Study

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Naiara Naiana Dejani ; Carolina F. Nicoletti ^[2] ; Perla Pizzi Argentato ^[3] ; Ludmilla da Silva Pereira ^[4] ; Amanda Correia Saraiva ^[5] ; Letícia Montanha de Assis ^[6] ; Patrícia Yury Nakandakare ^[7] ; Lívia Patricia Rodrigues Batista ^[8] ; Laísla de França da Silva Teles ^[9] ; Maria Paula Leitão ^[10] ; Liania Alves Luzia ^[11] ; Alexandra Ivo de Medeiros ; Patrícia Helen Rondó ^[13]

• Tipo de documento: Artigo Científico
• Fonte: Jornal de Pediatria; v. 99, n. 3, p. 284-288, 2023-06-16.

Resumo

Abstract Objective To investigate associations of maternal and cord blood cytokine patterns with newborn size and body composition. Methods This cross-sectional study involved 70 pregnant women and their healthy newborns selected from the “Araraquara Cohort Study”. Newborn anthropometric measurements were recorded at birth. Body composition was evaluated by air displacement plethysmography. Maternal blood samples were collected from pregnant women between 30 and 36 weeks of gestation, and umbilical cord blood samples were collected immediately after placenta discharge. The concentrations of the cytokines were determined in plasma by ELISA. Multiple linear regression models were used to assess associations between maternal and cord blood cytokine concentrations and newborn anthropometry and body composition measurements. Results Maternal plasma TGF-β1 concentration was inversely associated with newborn weight (β= -43.0; p= 0.012), length (β= -0.16, p= 0.028), head circumference (β= -0.13, p= 0.004), ponderal index (β= -0.32, p= 0.011) and fat-free mass (β= -0.05, p= 0.005). However, the association persisted just for head circumference (β= -0.26; p= 0.030) and ponderal index (β= - 0.28; p= 0.028), after adjusting for pre-gestational BMI, gestational weight gain, gestational age, hours after delivery, newborn sex, smoking and alcohol consumption. Conclusions Maternal plasma TGF-β1 concentration may be involved in the regulation of newborn size, mainly head circumference and ponderal index. Further cohort studies are necessary to investigate the role of TGF-β1 in different trimesters of pregnancy and its effect during the early stages of fetal development. (AU)

• Processo FAPESP: 15/03333-6 - Relação entre adiposidade materna e adiposidade do concepto nos períodos fetal, neonatal e no primeiro ano de vida: estudo prospectivo de base populacional
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/17824-0 - Perfil da metilação do DNA do binômio mãe-concepto no contexto da Obesidade materna e adiposidade fetal e neonatal
• Beneficiário: Perla Pizzi Argentato
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/19638-9 - Reprogramação metabólica de células dendríticas após eferocitose de células apoptóticas
• Beneficiário: Letícia de Aquino Penteado
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/07143-2 - Uma abordagem imunológica da relação entre adiposidade materna e do concepto nos períodos fetal, neonatal e no primeiro ano de vida
• Beneficiário: Naiara Naiana Dejani
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado