| Texto completo | |
| Autor(es): |
Gazarini, Lucas
;
Stern, Cristina A. J.
;
Bertoglio, Leandro J.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 147, p. 36-pg., 2023-02-21. |
| Resumo | |
Fear conditioning and avoidance tasks usually elicit adaptive aversive memories. Traumatic memories are more intense, generalized, inflexible, and resistant to attenuation via extinction- and reconsolidation-based strategies. Inducing and assessing these dysfunctional, maladaptive features in the laboratory are crucial to interrogating posttraumatic stress disorder's neurobiology and exploring innovative treatments. Here we analyze over 350 studies addressing this question in adult rats and mice. There is a growing interest in modeling several qualitative and quantitative memory changes by exposing already stressed animals to freezing- and avoidance-related tests or using a relatively high aversive training magnitude. Other options combine aversive/fearful tasks with postacquisition or post-retrieval administration of one or more drugs provoking neurochemical or epigenetic alterations reported in the trauma aftermath. It is potentially instructive to integrate these procedures and incorporate the measurement of autonomic and endocrine parameters. Factors to consider when defining the organismic and procedural variables, partially neglected aspects (sex-dependent differences and recent vs. remote data comparison) and suggestions for future research (identifying reliable individual risk and treatment-response predictors) are discussed. (AU) | |
| Processo FAPESP: | 17/24304-0 - Novas perspectivas no emprego de fármacos que modificam neurotransmissores atípicos no tratamento de transtornos neuropsiquiátricos |
| Beneficiário: | Francisco Silveira Guimaraes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |