A systematic review of the effects of cold exposure on pathological cardiac remodeling in mice

Autor(es)

Portes, Alexandre Martins Oliveira ; Paula, Ana Beatriz Rezende ; de Miranda, Denise Coutinho ; Resende, Leticia Teresinha ; Coelho, Bianca Iara Campos ; Teles, Maria Cecilia ; Jardim, Isabela Alcantara Barretto Araujo ; Natali, Antonio Jose ; Castrucci, Ana Maria de Lauro ; Isoldi, Mauro Cesar

• Tipo de documento: Artigo Científico
• Fonte: Journal of Thermal Biology; v. 114, p. 11-pg., 2023-06-13.

Resumo

Exposure to cold promotes cardiac remodeling, characterized by deleterious effects on structure and function, contributing to increased mortality from cardiovascular diseases. The mechanisms associated with these changes are poorly understood. This review gathers the literature data on the main alterations and mechanisms associated with the adverse cardiac structural and functional remodeling induced by cold exposure in mice. Original studies were identified by searching PubMed, Scopus, and Embase databases from January 1990 to June 2022. This systematic review was conducted in accordance with the criteria established by PRISMA and registered in PROSPERO (CRD42022350637). The risk of bias was evaluated by the SYRCLE. Eligible studies included original papers published in English that evaluated cardiac outcomes in mice submitted to short-or long-time cold exposure and had a control group at room temperature. Seventeen original articles were included in this review. Cold exposure induces pathological cardiac remodeling, characterized by detrimental structural and functional parameters, changes in metabolism and autophagy process, and increases in oxidative stress, inflammation, and apoptosis. In addition, Nppa, AT1A, Fbp3, BECN, ETA, and MT, appear to play fundamental roles in regulating cardiac remodeling. We suggest that strategies that seek to minimize the CVD risk and adverse effects of cold exposure should target these agents. (AU)

• Processo FAPESP: 18/14728-0 - Melanopsina como fotorreceptor de UVA e sua relação com pigmentação, reparo de DNA, relógio biológico e componentes do eixo HPA: um novo alvo farmacológico?
• Beneficiário: Ana Maria de Lauro Castrucci
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/24615-5 - Derrubando um paradigma? Melanopsina, um fotopigmento canônico, atuando como sensor para ajuste do relógio em órgãos não expostos à luz, e sua possível interação com canais TRP: estudo transdisciplinar envolvendo aspectos fisiológicos e patológicos
• Beneficiário: Ana Maria de Lauro Castrucci
• Modalidade de apoio: Auxílio à Pesquisa - Temático