Exploring the impact of hippocampal sclerosis on white matter tracts memory in individuals with mesial temporal lobe epilepsy

Autor(es):Mostrar menos -

Zanao, Tamires A. ; Seitz-Holland, Johanna ; O'Donnell, Lauren J. ; Zhang, Fan ; Rathi, Yogesh ; Lopes, Tatila M. ; Pimentel-Silva, Luciana Ramalho ; Yassuda, Clarissa L. ; Makris, Nikos ; Shenton, Martha E. ; Bouix, Sylvain ; Lyall, Amanda E. ; Cendes, Fernando

• Tipo de documento: Artigo Científico
• Fonte: EPILEPSIA OPEN; v. 8, n. 3, p. 12-pg., 2023-07-31.

Resumo

ObjectiveTo investigate how the presence/side of hippocampal sclerosis (HS) are related to the white matter structure of cingulum bundle (CB), arcuate fasciculus (AF), and inferior longitudinal fasciculus (ILF) in mesial temporal lobe epilepsy (MTLE). MethodsWe acquired diffusion-weighted magnetic resonance imaging (MRI) from 86 healthy and 71 individuals with MTLE (22 righ-HS; right-HS, 34 left-HS; left-HS, and 15 nonlesional MTLE). We utilized two-tensor tractography and fiber clustering to compare fractional anisotropy (FA) of each side/tract between groups. Additionally, we examined the association between FA and nonverbal (WMS-R) and verbal (WMS-R, RAVLT codification) memory performance for MTLE individuals. ResultsWhite matter abnormalities depended on the side and presence of HS. The left-HS demonstrated widespread abnormalities for all tracts, the right-HS showed lower FA for ipsilateral tracts and the nonlesional MTLE group did not differ from healthy individuals. Results indicate no differences in verbal/nonverbal memory performance between the groups, but trend-level associations between higher FA of visual memory and the left CB (r = 0.286, P = 0.018), verbal memory (RAVLT) and -left CB (r = 0.335, P = 0.005), -right CB (r = 0.286, P = 0.016), and -left AF (r = 0.287, P = 0.017). SignificanceOur results highlight that the presence and side of HS are crucial to understand the pathophysiology of MTLE. Specifically, left-sided HS seems to be related to widespread bilateral white matter abnormalities. Future longitudinal studies should focus on developing diagnostic and treatment strategies dependent on HS's presence/side. (AU)

• Processo FAPESP: 13/21056-4 - Estudo de espectrocospia de protons por ressonância magnética para determinação de biomarcadores inflamatórios e de refratariedade em epilepsia do lobo temporal.
• Beneficiário: Luciana Ramalho Pimentel da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/10433-0 - Estudo da conectividade funcional e estrutural e sua relação com distúrbios de memória em pacientes com epilepsia de lobo temporal mesial
• Beneficiário: Tamires Araujo Zanão Mariano
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/05393-4 - Caracterização de danos estruturais por imagem por tensor de difusão em pacientes com epilepsia de lobo temporal
• Beneficiário: Tamires Araujo Zanão Mariano
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs