Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution

Autor(es)

dos Santos, Nathalia Villa ; Vieira, Carolina Leticia Zilli ; Saldiva, Paulo Hilario Nascimento ; De Andre, Carmen Diva Saldiva ; Mazzilli, Barbara Paci ; Andrade, Maria de Fatima ; Saueia, Catia Heloisa ; Saiki, Mitiko ; Veras, Mariana Matera ; Koutrakis, Petros

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 12, n. 1, p. 7-pg., 2022-06-30.

Resumo

Heavy metals are natural and essential elements of the environment and living beings, produced from natural (e.g. volcanic activity and cosmic ray-induced spallation) and anthropogenic processes (e.g. industrial and fossil fuel combustion). High-concentrations of heavy metals and radionuclides are also originated from anthropogenic activities in urban and industrial areas. In this preliminary study, we analyzed the levels of heavy metals and Polonium-210 (Po-210) in lung tissues in autopsies from residents of the city of Sao Paulo, SP, Brazil. In order to identify the link among sources of the heavy metals in lungs, factor analysis was performed. Of the first four factors, which explain 66% of the total variability, three were associated with vehicular sources. The fitting of a regression model with Po-210 as the response variable and with the four factors as explanatory variables, controlling for age, sex and tobacco, showed a significant association between the concentration of polonium and the first factor that is generated by catalysts and brakes (coefficient = 0.90, standard error = 0.33, p = 0.016). Our findings suggest an association between traffic-related trace metals and Po-210 in lung autopsies. (AU)

• Processo FAPESP: 16/22793-0 - Doença de Alzheimer no epitélio olfatório: correlação com o meio ambiente
• Beneficiário: Nathalia Villa dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/21728-2 - Uso de modernas técnicas de autópsia na investigação de doenças humanas (MODAU)
• Beneficiário: Paulo Hilário Nascimento Saldiva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/03461-7 - Comparação da autópsia minimamente invasiva em relação à autópsia convencional para o diagnóstico post-mortem de neoplasias malignas
• Beneficiário: Lisie Tocci Justo Luvizutto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/23129-7 - Impacto da exposição crônica à poluição atmosférica no envelhecimento do miocárdio
• Beneficiário: Ana Paula Cremasco Takano
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado