Busca avançada
Ano de início
Entree


Multisensory Stimulation Reverses Memory Impairment in Adr & beta;3KO Male Mice

Texto completo
Autor(es):
Mostrar menos -
Ravache, Thais T. ; Batistuzzo, Alice ; Nunes, Gabriela G. ; Gomez, Thiago G. B. ; Lorena, Fernanda B. ; Do Nascimento, Bruna P. P. ; Bernardi, Maria Martha ; Lima, Eduarda R. R. ; Martins, Daniel O. ; Campos, Ana Carolina P. ; Pagano, Rosana L. ; Ribeiro, Miriam O.
Número total de Autores: 12
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 13, p. 17-pg., 2023-07-01.
Resumo

Norepinephrine plays an important role in modulating memory through its beta-adrenergic receptors (Adr & beta;: & beta;(1), & beta;(2) and & beta;(3)). Here, we hypothesized that multisensory stimulation would reverse memory impairment caused by the inactivation of Adr & beta;(3) (Adr & beta;3KO) with consequent inhibition of sustained glial-mediated inflammation. To test this, 21- and 86-day-old Adr & beta;3KO mice were exposed to an 8-week multisensory stimulation (MS) protocol that comprised gustatory and olfactory stimuli of positive and negative valence; intellectual challenges to reach food; the use of hidden objects; and the presentation of food in ways that prompted foraging, which was followed by analysis of GFAP, Iba-1 and EAAT2 protein expression in the hippocampus (HC) and amygdala (AMY). The MS protocol reduced GFAP and Iba-1 expression in the HC of young mice but not in older mice. While this protocol restored memory impairment when applied to Adr & beta;3KO animals immediately after weaning, it had no effect when applied to adult animals. In fact, we observed that aging worsened the memory of Adr & beta;3KO mice. In the AMY of Adr & beta;3KO older mice, we observed an increase in GFAP and EAAT2 expression when compared to wild-type (WT) mice that MS was unable to reduce. These results suggest that a richer and more diverse environment helps to correct memory impairment when applied immediately after weaning in Adr & beta;3KO animals and indicates that the control of neuroinflammation mediates this response. (AU)

Processo FAPESP: 19/13781-7 - Análise translacional dos mecanismos terapêuticos da estimulação cerebral profunda na Doença de Parkinson
Beneficiário:Rosana de Lima Pagano
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/18277-0 - Correlação entre o polimorfismo Thr92Ala da enzima iodotironina desiodase do tipo 2 (D2) e comportamento.
Beneficiário:Miriam Oliveira Ribeiro
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/04491-0 - Efeito do análogo do hormônio tireoideano seletivo para o TRbeta, GC-1, no cérebro de camundongos 3xTg-AD
Beneficiário:Bruna Pascarelli Pedrico Do Nascimento
Modalidade de apoio: Bolsas no Brasil - Doutorado