| Texto completo | |
| Autor(es): |
Pedrosa, Lucas de Freitas
;
Nascimento, Karen Reboucas
;
Soares, Caroline Giacomelli
;
de Oliveira, Debora Preceliano
;
de Vos, Paul
;
Fabi, Joao Paulo
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLANTS-BASEL; v. 12, n. 14, p. 21-pg., 2023-07-01. |
| Resumo | |
Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin's physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. One of the greater extents of recent pectin technological usage involves nanoencapsulation methods for many different compounds, ranging from chemotherapy and immunotherapy to natural extracts from fruits and other sources. Structural modification (modified pectin) is also utilized to enhance the use of dietary fiber. Although pectin is already recognized as a component of significant importance, there is still a need for a comprehensive review that delves into its intricate relationships with biological effects, which depend on the source and structure of pectin. This review covers all levels of clinical research, including cell culture, animal studies, and clinical trials, to understand how the plant source and pectin structures influence the biological effects in humans and some technological applications of pectin regarding human health. (AU) | |
| Processo FAPESP: | 22/12834-2 - Efeitos das pectinas modificadas na saúde intestinal: estudos pré-clínicos e clínicos para avaliar efeitos celulares, transcricionais e epigenéticos |
| Beneficiário: | Joao Paulo Fabi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/08063-5 - Estudo dos efeitos biológicos de pectinas modificadas de maracujá em modelo in vitro e in vivo de Carcinogênese de Cólon |
| Beneficiário: | Lucas de Freitas Pedrosa |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 22/12253-0 - Estudo in vitro da integridade intestinal humana e modulação de TLR após tratamento com pectina de maracujá modificada |
| Beneficiário: | Lucas de Freitas Pedrosa |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos |
| Beneficiário: | Bernadette Dora Gombossy de Melo Franco |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |