Busca avançada
Ano de início
Entree


Plant-derived polyphenolic compounds: nanodelivery through polysaccharide-based systems to improve the biological properties

Texto completo
Autor(es):
Rosales, Thiecla Katiane Osvaldt ; da Silva, Fabio Fernando Alves ; Bernardes, Emerson Soares ; Fabi, Joao Paulo
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; v. N/A, p. 25-pg., 2023-08-04.
Resumo

Plant-derived polyphenols are naturally occurring compounds widely distributed in plants. They have received greater attention in the food and pharmaceutical industries due to their potential health benefits, reducing the risk of some chronic diseases due to their antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuro-action properties. Polyphenolic compounds orally administered can be used as adjuvants in several treatments but with restricted uses due to chemical instability. The review discusses the different structural compositions of polyphenols and their influence on chemical stability. Despite the potential and wide applications, there is a need to improve the delivery of polyphenolics to target the human intestine without massive chemical modifications. Oral administration of polyphenols is unfeasible due to instability, low bioaccessibility, and limited bioavailability. Nano-delivery systems based on polysaccharides (starch, pectin, chitosan, and cellulose) have been identified as a viable option for oral ingestion, potentiate biological effects, and direct-controlled delivery in specific tissues. The time and dose can be individualized for specific diseases, such as intestinal cancer. This review will address the mechanisms by which polysaccharides-based nanostructured systems can protect against degradation and enhance intestinal permeation, oral bioavailability, and the potential application of polysaccharides as nanocarriers for the controlled and targeted delivery of polyphenolic compounds. (AU)

Processo FAPESP: 22/12834-2 - Efeitos das pectinas modificadas na saúde intestinal: estudos pré-clínicos e clínicos para avaliar efeitos celulares, transcricionais e epigenéticos
Beneficiário:Joao Paulo Fabi
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
Beneficiário:Bernadette Dora Gombossy de Melo Franco
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 23/09620-3 - Nanocarreadores de Antocianinas à Base De Pectina e Lisozima: Abordagem Experimental para Avaliação do Aumento da Biodisponibilidade e dos Efeitos Anticancerígenos no Cólon de Ratos
Beneficiário:Thiécla Katiane Osvaldt Rosales
Modalidade de apoio: Bolsas no Brasil - Programa Fixação de Jovens Doutores
Processo FAPESP: 23/01396-7 - Nanocarreadores de Antocianinas à Base de Pectina e Lisozima: Abordagem Experimental para Avaliação do Aumento da Biodisponibilidade e dos Efeitos Anticancerígenos no Cólon de Ratos
Beneficiário:Joao Paulo Fabi
Modalidade de apoio: Auxílio à Pesquisa - Regular