| Texto completo | |
| Autor(es): Mostrar menos - |
Silva, Raphael Tristao Cruvinel
;
Guidotti-Takeuchi, Micaela
;
Peixoto, Jessica Laura Miranda
;
Demarqui, Fernanda Manaia
;
Mori, Ananda Paula
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Dumont, Carolyne Ferreira
;
Ferreira, Gabriella Rayane Aparecida
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Pereira, Gabriele de Menezes
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Rossi, Daise Aparecida
;
Corbi, Pedro Paulo
;
Pavan, Fernando Rogerio
;
Rezende Junior, Celso de Oliveira
;
de Melo, Roberta Torres
;
Guerra, Wendell
Número total de Autores: 14
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| Tipo de documento: | Artigo Científico |
| Fonte: | Molecules; v. 28, n. 9, p. 16-pg., 2023-05-05. |
| Resumo | |
This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)(2)] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)(2)] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1-4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 mu g/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 mu g/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance. (AU) | |
| Processo FAPESP: | 21/08717-8 - Síntese de complexos de cobre, prata e ouro envolvendo análogos de nucleotídeos na busca por novas alternativas para o tratamento do câncer de ovário |
| Beneficiário: | Pedro Paulo Corbi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |