| Texto completo | |
| Autor(es): Mostrar menos - |
Ruiz, Thalles F. R.
;
Colleta, Simone J.
;
dos Santos, Diego D.
;
Castro, Nayara F. C.
;
Cabral, Agata S.
;
Calmon, Marilia F.
;
Rahal, Paula
;
Gil, Cristiane D.
;
Girol, Ana Paula
;
Vilamaior, Patricia S. L.
;
Leonel, Ellen C. R.
;
Taboga, Sebastiao R.
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Cell Biology International; v. 47, n. 6, p. 11-pg., 2023-03-11. |
| Resumo | |
Inflammation in the established tumor microenvironment (TME) is often associated with a poor prognosis of breast cancer. Bisphenol A (BPA) is an endocrine-disrupting chemical that acts as inflammatory promoter and tumoral facilitator in mammary tissue. Previous studies demonstrated the onset of mammary carcinogenesis at aging when BPA exposure occurred in windows of development/susceptibility. We aim to investigate the inflammatory repercussions of BPA in TME in mammary gland (MG) during neoplastic development in aging. Female Mongolian gerbils were exposed to low (50 mu g/kg) or high BPA (5000 mu g/kg) doses during pregnancy and lactation. They were euthanized at 18 months of age (aging) and the MG were collected for inflammatory markers and histopathological analysis. Contrarily to control MG, BPA induced carcinogenic development mediated by COX-2 and p-STAT3 expression. BPA was also able to promote macrophage and mast cell (MC) polarization in tumoral phenotype, evidenced by pathways for recruitment and activation of these inflammatory cells and tissue invasiveness triggered by tumor necrosis factor-alpha and transforming growth factor-beta 1 (TGF-beta 1). Increase of tumor-associated macrophages, M1 (CD68 + iNOS+) and M2 (CD163+) expressing pro-tumoral mediators and metalloproteases was observed; this aspect greatly contributed to stromal remodeling and invasion of neoplastic cells. In addition, the MC population drastically increased in BPA-exposed MG. Tryptase-positive MCs increased in disrupted MG and expressed TGF-beta 1, contributing to EMT process during carcinogenesis mediated by BPA. BPA exposure interfered in inflammatory response by releasing and enhancing the expression of mediators that contribute to tumor growth and recruitment of inflammatory cells that promote a malignant profile. (AU) | |
| Processo FAPESP: | 20/00160-1 - Efeitos da exposição materna ao bisfenol A sobre próstata de gerbilos (Meriones unguiculatus) adultos e senescentes |
| Beneficiário: | Simone Jacovaci Colleta |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/23383-6 - Repercussões histopatológicas da ação dos desreguladores endócrinos bisfienol-A e 17-beta-estradiol sobre glândulas mamárias e próstata feminina do Gerbilo da Mongólia e suas relações com a carcinogênese quimicamente induzida pelo MNU |
| Beneficiário: | Sebastião Roberto Taboga |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/01240-9 - Efeitos tardios da exposição ao bisfenol A na mama de fêmeas de gerbilos durante o período gestacional e lactacional |
| Beneficiário: | Thalles Fernando Rocha Ruiz |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |