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Inherited pain hypersensitivity and increased anxiety-like behaviors are associated with genetic epilepsy in Wistar Audiogenic Rats: Short- and long-term effects of acute and chronic seizures on nociception and anxiety

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Autor(es):
Lazarini-Lopes, Willian ; Silva-Cardoso, Gleice Kelli ; Cortes de Oliveira, Jose Antonio ; Correa Passos, Luiz Augusto ; Salgado, Andreia Ruis ; Rodrigues Demolin, Daniele Masselli ; Andrade Leite-Panissi, Christie Ramos ; Garcia-Cairasco, Norberto ; Coimbra, Norberto Cysne
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: Epilepsy & Behavior; v. 141, p. 13-pg., 2023-03-10.
Resumo

Anxiety and pain hypersensitivity are neurobehavioral comorbidities commonly reported by patients with epilepsies, and preclinical models are suitable to investigate the neurobiology of behavioral and neuropathological alterations associated with these epilepsy-related comorbidities. This work aimed to characterize endogenous alterations in nociceptive threshold and anxiety-like behaviors in the Wistar Audiogenic Rat (WAR) model of genetic epilepsy. We also assessed the effects of acute and chronic sei-zures on anxiety and nociception. WARs from acute and chronic seizure protocols were divided into two groups to assess short-and long-term changes in anxiety (1 day or 15 days after seizures, respec-tively). To assess anxiety-like behaviors, the laboratory animals were submitted to the open field, light-dark box, and elevated plus maze tests. The von Frey, acetone, and hot plate tests were used to mea-sure the endogenous nociception in seizure-free WARs, and postictal antinociception was recorded at 10, 30, 60, 120, 180 min, and 24 h after seizures. Seizure-free WARs presented increased anxiety-like behav-iors and pain hypersensitivity, displaying mechanical and thermal allodynia (to heat and cold stimuli) in comparison to nonepileptic Wistar rats. Potent postictal antinociception that persisted for 120 to 180 min was detected after acute and chronic seizures. Additionally, acute and chronic seizures have magnified the expression of anxiety-like behaviors when assessed at 1 day and 15 days after seizures. Behavioral analysis indicated more severe and persistent anxiogenic-like alterations in WARs submitted to acute sei-zures. Therefore, WARs presented pain hypersensitivity and increased anxiety-like behaviors endoge-nously associated with genetic epilepsy. Acute and chronic seizures induced postictal antinociception in response to mechanical and thermal stimuli and increased anxiety-like behaviors when assessed 1 day and 15 days later. These findings support the presence of neurobehavioral alterations in subjects with epilepsy and shed light on the use of genetic models to characterize neuropathological and behav-ioral alterations associated with epilepsy.(c) 2023 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 21/14198-3 - Epilepsias e comorbidades neuropsiquiátricas: caracterização dos efeitos do tratamento com canabidiol e huf-101 em modelos experimentais in vivo e in vitro
Beneficiário:Willian Lazarini Lopes
Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
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Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
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Modalidade de apoio: Auxílio à Pesquisa - Regular
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Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/05957-8 - Epilepsias e comorbidades neuropsiquiátricas: caracterização dos efeitos do tratamento com canabidiol e HUF-101 em modelos experimentais in vivo e in vitro
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Modalidade de apoio: Auxílio à Pesquisa - Regular
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Modalidade de apoio: Bolsas no Brasil - Doutorado