| Texto completo | |
| Autor(es): |
Capitani, Caroline D.
;
Carvalho, Ana C. L.
;
Botelho, Patricia B.
;
Carrapeiro, Mariana M.
;
Castro, Inar A.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY; v. 111, n. 11, p. 11-pg., 2009-11-01. |
| Resumo | |
Despite the increase in the use of natural compounds in place of synthetic derivatives as antioxidants in food products, the extent of this substitution is limited by cost constraints. Thus, the objective of this study was to explore the synergism on the antioxidant activity of natural compounds, for further application in food products. Three hydrosoluble compounds (x(1) = caffeic acid, x(2) = carnosic acid, and x(3) = glutathione) and three liposoluble compounds (x(1) = quercetin, x(2) = rutin, and x(3) = genistein) were mixed according to a "centroid simplex design". The antioxidant activity of the mixtures was analyzed by the ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAL) methodologies, and activity was also evaluated in an oxidized mixed micelle prepared with linoleic acid (LAOX). Cubic polynomial models with predictive capacity were obtained when the mixtures were submitted to the LAOX methodology ((y) over cap = 0.56 x(1) + 0.59 x(2) + 0.04 x(3) + 0.41 x(1)x(2) - 0.41 x(1)x(3) - 1.12 x(2)x(3) - 4.01 x(1)x(2)x(3)) for the hydrosoluble compounds, and to FRAP methodology ((y) over cap = 3.26 x(1) + 2.39 x(2) + 0.04 x(3) + 1.51 x(1)x(2) + 1.03 x(1)x(3) + 0.29 x(1)x(3) + 3.20 x(1)x(2)x(3)) for the liposoluble compounds. Optimization of the models suggested that a mixture containing 47% caffeic acid + 53% carnosic acid and a mixture containing 67% quercetin + 33% rutin were potential synergistic combinations for further evaluation using a food matrix. (AU) | |
| Processo FAPESP: | 07/05770-8 - Efeito do uso combinado de ácidos graxos polinsaturados ômega 3 e estatinas nos biomarcadores do stress oxidativo em indivíduos com dislipidemia |
| Beneficiário: | Mariana de Magalhães Carrapeiro |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 07/01476-8 - Efeito da dieta na variacao de biomarcadores do stress oxidativo em individuos com dislipidemia. |
| Beneficiário: | Patrícia Borges Botelho Gamba |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 06/07136-1 - Modelagem matematica na avaliacao do sinergismo da atividade antioxidante de compostos naturais aplicados em emulsoes alimenticias. |
| Beneficiário: | Inar Castro Erger |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |