Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

Autor(es)

Pezato, Rogerio ; de Almeida, Danilo Candido ; Bezerra, Thiago Freire ; Silva, Fernando de Sa ; Perez-Novo, Claudina ; Gregorio, Luis Carlos ; Voegels, Richard Louis ; Camara, Niels Olsen ; Bachert, Claus

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2014, p. 11-pg., 2014-01-01.

Resumo

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+ CD25+ Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition. (AU)

• Processo FAPESP: 10/12295-7 - Caracterização do perfil de expressão de microRNAs no reparo tecidual e celular induzido por células-tronco mesenquimais derivadas do tecido adiposo em modelos in vitro e in vivo de lesão renal aguda.
• Beneficiário: Danilo Candido de Almeida
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/02270-2 - Novos mecanismos celulares, moleculares e imunológicos das lesões renais agudas e crônicas: busca por novas estratégias terapêuticas
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático